Recent advances in research on cognitive frailty and related conditions

Cognitive frailty (CF) is an age-related condition characterized by the comorbidity of physical frailty and cognitive impairment. This includes reduced cognitive function due to physical and brain diseases, as well as accelerated brain aging in the absence of manifest brain diseases like dementia. CF in associated with a high risk of adverse events such as dementia, the need for nursing care, hospitalization, disability, and death. It is important to note that CF is reversible and adverse events can be prevented with early detection and intervention. Therefore, research on CF has increased rapidly in various fields in recent years.



This Research Topic aims to elucidate the latest advances in the field of basic and clinical research on CF. Specifically, we will focus on areas such as epidemiology, mechanisms, biomarkers, and interventions.



This Research Topic welcomes various article types, including original research articles, reviews, mini-reviews, systematic reviews, clinical trials, case reports, perspectives, short communications as well as theoretical papers, opinions, and study protocols relevant to this article collection that will cover topics such as (but not limited to):



・Epidemiological research on CF

・Research on the pathological mechanism of CF

・Research on biomarkers for early detection of CF

・Research on risk factors for CF

・Research on evidence regarding rehabilitation for CF

・Research on sports intervention for CF

・Research on new intervention methods for CF

・Research on animal models of CF

・Research on pathological conditions related to CF (i.e., subjective cognitive decline, mild cognitive impairment, mild behavioral impairment, motoric cognitive risk syndrome, etc)

・Other research