About this Research Topic
Genitourinary (GU) cancers include some of the most common solid malignancies, such as prostate, uterine cervix, kidney and bladder cancers, as well as less common cancers such as penile, vaginal and vulvar squamous cell carcinomas. Studies focused on human papillomavirus (HPV) have a major impact in the field of gynecology, especially in cervical cancer. However, further research is required to understand the impact of HPV in genitourinary oncology at large and the impact it may have on genitourinary cancers besides cervical cancer. In fact, studies have demonstrated that HPV-16 is the primary HPV type (60%) found in invasive penile tumors followed by HPV-18 and HPV types 6/11. However, the role of HPV in lesions such as prostate and bladder cancer remains far from clear. While some studies suggest that there is no difference in HPV expression between cancerous and non-cancerous prostatic tissues, other studies highlighted HPV-16-E6 protein expression in prostate cancer in comparison with prostate adenomas, which suggest that HPV-16 may play a role in prostate oncobiology. The aim of this Research Topic is to understand how HPV impacts GU oncology at large, and how it influences the natural history of genitourinary cancers in patients, including patient prognosis.
The Research Topic will accept research dealing with the potential causal role of HPV in GU cancers not usually associated with this virus. Studies focusing on the potential association of HPV with prostate and bladder cancers are of particular interest. Articles focused on cancers that are recognized to be associated with HPV, such as cervical, vaginal, vulvar and penile squamous cell carcinomas will also be considered. Basic, clinical and translational studies dealing with mechanisms of carcinogenesis, tumor morphological and molecular features and patient prognosis are of interest.
We welcome Original Research, Reviews, Systematic Reviews and Mini-Reviews in all types of genitourinary cancers, including basic, translational and clinical works. Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
The Research Topic will accept research dealing with the potential causal role of HPV in GU cancers not usually associated with this virus. Studies focusing on the potential association of HPV with prostate and bladder cancers are of particular interest. Articles focused on cancers that are recognized to be associated with HPV, such as cervical, vaginal, vulvar and penile squamous cell carcinomas will also be considered. Basic, clinical and translational studies dealing with mechanisms of carcinogenesis, tumor morphological and molecular features and patient prognosis are of interest.
We welcome Original Research, Reviews, Systematic Reviews and Mini-Reviews in all types of genitourinary cancers, including basic, translational and clinical works. Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Keywords: HPV, genitourinary, oncology, cancer
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
