About this Research Topic
The overarching goal of this Research Topic is to begin to understand how the secretion of the SASP contributes to the diverse phenotypes driven by the presence of senescent cells both in healthy aging and in diseases situations. As novel technologies allow the identification of expressed and secreted factors at the single cell level, recognizing the context- and cell-specific range of the SASP becomes possible. Additionally, the generation of in vivo and ex vivo models that faithfully recapitulate the gamut of cells, including immune cells, present in a given organ or tissue, now allows the determination of the impact of the SASP on a complex network of cellular interactions. By combining these approaches, it becomes possible to understand how the SASP affects normal and pathological conditions both at the molecular and the cellular levels.
We welcome the submission of review and original research articles that cover the following aspects, but are not limited to:
• Molecular events leading to the activation of a secretory phenotype in senescent cells
• Heterogeneity of the SASP among senescent cells, based either on the cell of origin or the inducer of senescence.
• Paracrine versus autocrine effects of the SASP
• Impact of the SASP on immune cells recruitment, activation and elimination in normal contexts, disease and aging
• Contribution of individual SASP factors to the "inflamm-aging"
• Identification of non-protein SASP factor
Keywords: Senescence, SASP, heterogeneity, cytokines, inflammation, cellular aging
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.