About this Research Topic
The ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) are notorious for their ability to escape from conventional antibiotics.
Biofilm formation, a key virulence factor exhibited by these pathogens, further complicates the treatment strategies. The development of biofilm inhibitors against ESKAPE pathogens is crucial due to the rising threat of AMR and the challenges posed by persistent infections. ESKAPE pathogens are adept at forming biofilms, protective structures that significantly contribute to their resilience against conventional antibiotics. These biofilms not only enhance the pathogen’s virulence and ability to cause chronic infections but also pose a particular risk in medical settings, where they can adhere to and form biofilms on various medical devices.
Overcoming these challenges necessitates the development of biofilm inhibitors to improve the efficacy of existing treatments, mitigate the risk of device-associated infections, and address the broader public health concern of multi-drug resistant pathogens. In essence, the pursuit of biofilm inhibitors is a proactive strategy to confront the evolving landscape of infectious diseases and ensure effective therapeutic interventions.
This research topic welcomes contributions of original research, review, mini-review, opinion, delves into diverse strategies for combating ESKAPE pathogens through the inhibition of biofilms, encompassing a range of approaches and methodologies.
This will be focused on exploring various anti-biofilm strategies as follows:
• Natural products
• Synthetic and semi-synthetic drug candidates
• Essential oils
• Antibiofilm Peptides
• Quorum quenching enzymes
• Nanoparticles
• Prebiotics, Probiotics and synbiotics and
• Phage therapy
Keywords: Antimicrobial resistance, Biofilm Inhibitors, ESKAPE Pathogens, Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter species
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.