About this Research Topic
Plants have long been used by humans for different therapeutical strategies. Their beneficial action is influenced by metabolites of different chemical structures that play crucial roles for the plants, but also exhibit various biological actions when used in humans. Many plant species have been widely used around the world in different traditional medicines, and still, nowadays more than 80 % of people rely on plants. Different chemical scaffoldings detected in plant extracts are inspiring scientists to develop other semi-synthetic derivatives that are being used as efficient drugs with a better pharmacokinetic profile.
Polyphenols belong to secondary metabolites that play a special role in the treatment of human free radicals-linked diseases. This diverse group of metabolites, containing all organic compounds with hydroxyl groups on an aromatic ring, is represented mainly by phenolic acids, flavonoids, anthocyanins, tannins, lignans, stilbenes, and others.
Numerous scientific papers confirm the strong biological potential of polyphenols and their important role in the treatment of civilization diseases. At the same time, this class of compounds is notorious for resulting in false positive data most notably in in vitro studies, often classed as ‘pan assay interfering substances. Consequently, the pharmacological relevance of many datasets is at best controversial, Therefore, the attention paid to the identification of polyphenolic compounds in plant material and their isolation from the plant matrix is of the highest importance. Together with an increased efficiency of analytical equipment, the isolation of single molecules of high purity is possible and triggers further pharmacological investigations on their impact on human health.
Medicinal plants are the primary sources of natural active components. Due to their rich chemical composition, dried plant material, plant parts and extracts can exhibit therapeutic effects in humans. The significance of medicinal plants in developing novel medications to treat various ailments is a promising line of scientific research. With the help of modern analytical methodologies, the recovery of single components from plant matrices or the preparation of enriched extracts is possible. It creates an opportunity to perform detailed studies on isolated compounds and better understand the impact of natural products on living organisms. This Research Topic aims to collect scientific evidence that can be useful for identifying novel pharmacological evidence for known substances and new substances of pharmacological value in plants and also to present possible methods for their recovery from plant material on analytical and industrial scales. Simultaneously, by using suitable methods and control experiments, the research topic will help to overcome the challenges associated with the problem of pan-assay interference.
Considering the above, this Research Topic invites submissions for the identification of new bioactive polyphenols or those already known ones that are being described as very highly active for the first time. Manuscripts must focus on their isolation protocols, and studies on their pharmacological potential. We encourage submissions in the form of Original Research, Reviews, or Short Communications on the application of raw plant material (flowering plants, cereals, fruits, and vegetables). The recent developments in the separation methodology and structure elucidation of natural products can be highlighted, together with the potential application of the isolates as pharmacologically active molecules. The mechanisms involved in the studied biological activities (e.g., antioxidant, anti-inflammatory, antimicrobial, antiviral, anticancer effects, or others) are also of interest. With this collection, we aim to shed new light on the natural polyphenols - their origin, isolation methodology, and applications, especially in the pharmaceutical, food, and cosmetic industries.
The submissions to this Research Topic should highlight the following:
• Optimization studies on plant material
• Fingerprinting of plant extracts in terms of the pharmacological potential of single components
• Isolation protocols that could lead to a recovery of pharmacologically potent molecules from the total extracts
• Application of green chemistry principles in the preparation of plant drugs
• Impact of polyphenols on the biological functions of living organisms
• Investigation of the molecular mechanisms of polyphenols’ activity
All the manuscripts submitted to the collection will need to fully comply with the Four Pillars of Best Practice in Ethnopharmacology (you can freely download the full version here). Please self-assess your MS using the ConPhyMP tool, and follow the standards established in the ConPhyMP statement Front. Pharmacol. 13:953205. Please note the traditional context including the primary background and modern uses with supporting references must be included in the manuscript introduction.
If your MS involves plant or fungal extracts, check your MS using this tool.
Polyphenols belong to secondary metabolites that play a special role in the treatment of human free radicals-linked diseases. This diverse group of metabolites, containing all organic compounds with hydroxyl groups on an aromatic ring, is represented mainly by phenolic acids, flavonoids, anthocyanins, tannins, lignans, stilbenes, and others.
Numerous scientific papers confirm the strong biological potential of polyphenols and their important role in the treatment of civilization diseases. At the same time, this class of compounds is notorious for resulting in false positive data most notably in in vitro studies, often classed as ‘pan assay interfering substances. Consequently, the pharmacological relevance of many datasets is at best controversial, Therefore, the attention paid to the identification of polyphenolic compounds in plant material and their isolation from the plant matrix is of the highest importance. Together with an increased efficiency of analytical equipment, the isolation of single molecules of high purity is possible and triggers further pharmacological investigations on their impact on human health.
Medicinal plants are the primary sources of natural active components. Due to their rich chemical composition, dried plant material, plant parts and extracts can exhibit therapeutic effects in humans. The significance of medicinal plants in developing novel medications to treat various ailments is a promising line of scientific research. With the help of modern analytical methodologies, the recovery of single components from plant matrices or the preparation of enriched extracts is possible. It creates an opportunity to perform detailed studies on isolated compounds and better understand the impact of natural products on living organisms. This Research Topic aims to collect scientific evidence that can be useful for identifying novel pharmacological evidence for known substances and new substances of pharmacological value in plants and also to present possible methods for their recovery from plant material on analytical and industrial scales. Simultaneously, by using suitable methods and control experiments, the research topic will help to overcome the challenges associated with the problem of pan-assay interference.
Considering the above, this Research Topic invites submissions for the identification of new bioactive polyphenols or those already known ones that are being described as very highly active for the first time. Manuscripts must focus on their isolation protocols, and studies on their pharmacological potential. We encourage submissions in the form of Original Research, Reviews, or Short Communications on the application of raw plant material (flowering plants, cereals, fruits, and vegetables). The recent developments in the separation methodology and structure elucidation of natural products can be highlighted, together with the potential application of the isolates as pharmacologically active molecules. The mechanisms involved in the studied biological activities (e.g., antioxidant, anti-inflammatory, antimicrobial, antiviral, anticancer effects, or others) are also of interest. With this collection, we aim to shed new light on the natural polyphenols - their origin, isolation methodology, and applications, especially in the pharmaceutical, food, and cosmetic industries.
The submissions to this Research Topic should highlight the following:
• Optimization studies on plant material
• Fingerprinting of plant extracts in terms of the pharmacological potential of single components
• Isolation protocols that could lead to a recovery of pharmacologically potent molecules from the total extracts
• Application of green chemistry principles in the preparation of plant drugs
• Impact of polyphenols on the biological functions of living organisms
• Investigation of the molecular mechanisms of polyphenols’ activity
All the manuscripts submitted to the collection will need to fully comply with the Four Pillars of Best Practice in Ethnopharmacology (you can freely download the full version here). Please self-assess your MS using the ConPhyMP tool, and follow the standards established in the ConPhyMP statement Front. Pharmacol. 13:953205. Please note the traditional context including the primary background and modern uses with supporting references must be included in the manuscript introduction.
If your MS involves plant or fungal extracts, check your MS using this tool.
Keywords: plant polyphenols, pharmacological approaches, isolation, natural products, separation methodology, structure elucidation, bioactivity
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
