Comparative Coagulation Profiles and Clot Function in Veterinary Medicine: Unravelling Species-Specific Hemostatic Mechanisms and Fibrin Meshwork Structures

Nature has equipped different species with unique hemostatic pathways that are crucial for their survival. These pathways, which involve proteases, cofactors, and a balance of positive and negative feedback loops, are present in all vertebrates. However, variations exist in the quantity and quality of coagulation factors, leading to subtle changes in the intricate network of molecular interactions. Furthermore, while the general structure of the fibrinogen molecule is well conserved among species, the α- and γ-chains display species-specific variability, resulting in different stiffness and deformability of blood clots.

The primary aim of this Research Topic is to delve deeper into and compare coagulation research across various animal species, illuminating the unique nuances of hemostatic mechanisms in each. The contributions may include studies on coagulation factors, platelet function, fibrin function, and overall hemostasis in a range of animals, including mammals, birds, and reptiles. A comparative analysis with the human hemostatic system is also encouraged. Through this approach, the goal is to enhance our understanding of the complexities of coagulation cascades across species and their potential implications for veterinary medicine and translational research. Additionally, research on the structure-function relationships of animal fibrin clots can contribute to a better understanding of fibrous hydrogel mechanics, which is relevant for the creation of fibrous scaffolds for tissue repair and regenerative medicine.

We also welcome articles addressing the normal hemostasis and pathological conditions, providing a comprehensive view of coagulation and clot formation/deformability in the animal kingdom. If possible, we also encourage authors to discuss species-specific laboratory procedures and methods.