About this Research Topic
An adequate and balanced response to pathogenic factors is one of the conditions that determine the survival of an individual, a population, or even an entire species. Clinical data collected during the COVID-19 pandemic showed that a patients’ resistance varied, depending on their levels of well-known endocrine system regulators, e.g., vitamin D. In addition, the imbalance of hormonal milieu in women increases the prevalence rate for autoimmune diseases compared to men, whilst exposure to endocrine disruptors negatively affects the development of the immune system in offspring leading to later health defects. All of the above proves that understanding the linkage between the endocrine and immune system is necessary to propose new therapeutic strategies helping improve the lives of those with disease and illness.
It is known that restoring the endocrine system balance through ligand-mediated modulation of GPCR signaling improves the functioning of both innate and adaptive immune systems. Thus, an excessive immune response demonstrated that acute or chronic inflammation can be controlled differently than through commonly used immunosuppressive drugs. There is therefore much more to be discovered from learning the relationship between these two systems.
This topic aims to understand and explore the mutual interactions between the endocrine and immune systems. Newly discovered crosstalks in cellular signaling or novel protein regulators of immune response will be of high interest. Original articles or reviews proposing new therapeutic strategies for immune diseases are of particular interest. Biological and computational approaches to elucidate mechanisms of action of endocrine and immune systems components are welcome.
Themes of interest include, but are not limited to:
• Molecular interactions between the Endocrine and Immunity systems
• Cross talk and cellular signalling of the Immune and Endocrine systems
• The importance of Hormonal balance in Immunity and Endocrine systems
• New therapeutic strategies aimed at improving the interaction between these two systems
It is known that restoring the endocrine system balance through ligand-mediated modulation of GPCR signaling improves the functioning of both innate and adaptive immune systems. Thus, an excessive immune response demonstrated that acute or chronic inflammation can be controlled differently than through commonly used immunosuppressive drugs. There is therefore much more to be discovered from learning the relationship between these two systems.
This topic aims to understand and explore the mutual interactions between the endocrine and immune systems. Newly discovered crosstalks in cellular signaling or novel protein regulators of immune response will be of high interest. Original articles or reviews proposing new therapeutic strategies for immune diseases are of particular interest. Biological and computational approaches to elucidate mechanisms of action of endocrine and immune systems components are welcome.
Themes of interest include, but are not limited to:
• Molecular interactions between the Endocrine and Immunity systems
• Cross talk and cellular signalling of the Immune and Endocrine systems
• The importance of Hormonal balance in Immunity and Endocrine systems
• New therapeutic strategies aimed at improving the interaction between these two systems
Keywords: Immunity, Endocrine, Hormones, Crosstalk, Molecular, Inflammation
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