A dazzling array of biomaterials have been engineered for therapeutic and diagnostic applications, with many products entering clinical trials and markets. For example, lipid/mRNA vaccines and medical devices such as extracorporeal membrane oxygenation (ECMO) machines have played critical roles in coping with the coronavirus disease 2019 (COVID-19) pandemic. Building on multidisciplinary development, the past few decades have witnessed the evolution of biomaterials from static and biologically inert entities to more active and smart systems, which aim at improving the function of biomaterials. However, there is still a gap between biomaterials in the laboratory and the desired bioactive systems. One major reason is that the intricate interaction between biomaterials and biologic systems—which lays a foundation for biomaterials design—is still not fully understood.
In this topic, we will intensively focus on the understanding of intricate interaction at biointerfaces and how to manipulate interaction by elaborate materials design. The manipulation enables the control of protein binding, cell adhesion/growth/differentiation, and organ/tissue/cell targeting, which would render desired biological responses such as biocompatibility and specific functions. The following research areas can be touched upon (but certainly not limited to these):
(i) new biomaterials design and biocompatibility evaluation;
(ii) stealth and anti-fouling coating;
(iii) medical devices;
(iv) tissue engineering and regeneration;
(v) drug delivery and nanomedicine.
The specific application of bioactive biomaterials concerned with disease treatment (e.g., cancer, neurological disorders, inflammatory diseases, and metabolic diseases), prevention of infectious diseases (e.g., viruses or bacteria-related ones), and improvement of aging society with health and longevity are further welcome. We would like to collect your precious work intended to serve as a forum for a shared goal—surmounting the current challenges in the design and application of bioactive biomaterials based on biointerfacial dissection and manipulation.
Keywords:
biomaterial design, interactions at biointerfaces, biocompatibility, stealth and anti-fouling coating, medical devices, tissue engineering and regeneration, drug delivery, nanomedicine
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
A dazzling array of biomaterials have been engineered for therapeutic and diagnostic applications, with many products entering clinical trials and markets. For example, lipid/mRNA vaccines and medical devices such as extracorporeal membrane oxygenation (ECMO) machines have played critical roles in coping with the coronavirus disease 2019 (COVID-19) pandemic. Building on multidisciplinary development, the past few decades have witnessed the evolution of biomaterials from static and biologically inert entities to more active and smart systems, which aim at improving the function of biomaterials. However, there is still a gap between biomaterials in the laboratory and the desired bioactive systems. One major reason is that the intricate interaction between biomaterials and biologic systems—which lays a foundation for biomaterials design—is still not fully understood.
In this topic, we will intensively focus on the understanding of intricate interaction at biointerfaces and how to manipulate interaction by elaborate materials design. The manipulation enables the control of protein binding, cell adhesion/growth/differentiation, and organ/tissue/cell targeting, which would render desired biological responses such as biocompatibility and specific functions. The following research areas can be touched upon (but certainly not limited to these):
(i) new biomaterials design and biocompatibility evaluation;
(ii) stealth and anti-fouling coating;
(iii) medical devices;
(iv) tissue engineering and regeneration;
(v) drug delivery and nanomedicine.
The specific application of bioactive biomaterials concerned with disease treatment (e.g., cancer, neurological disorders, inflammatory diseases, and metabolic diseases), prevention of infectious diseases (e.g., viruses or bacteria-related ones), and improvement of aging society with health and longevity are further welcome. We would like to collect your precious work intended to serve as a forum for a shared goal—surmounting the current challenges in the design and application of bioactive biomaterials based on biointerfacial dissection and manipulation.
Keywords:
biomaterial design, interactions at biointerfaces, biocompatibility, stealth and anti-fouling coating, medical devices, tissue engineering and regeneration, drug delivery, nanomedicine
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.