About this Research Topic
The Research Topic seeks to explore the wide range of biological processes controlled by cell communication signaling networks in normal and pathological conditions using state-of-the-art techniques and multi-omics methods. Three key areas are the focus of our major goal: (I) intercellular junctions with barrier functions (II) cell adhesion molecules which primarily ensure the interaction of cells with the ECM and (III) actin-rich protrusions such as podosomes in normal cells and invadopodia in cancer cells promoting cell motility. It is important to note that the listed cell communication modalities are associated with multiple different processes, including but not limited to maintaining cerebrovascular integrity, contributing in epithelial-mesenchymal transition (EMT), or coordinating the motility stages of metastatic process. Thus, studies focusing on the most recent advancements and discoveries in cancer cell motility research are particularly appreciated. The analysis of intercellular communication regulation holds great importance in tumor diagnosis, as it may provide potential biomarkers for early detection and enable development of more efficient treatment strategies. Our goal is to showcase novel findings regarding the diverse aspects and effects of cell communication modalities.
Authors can contribute to this Research Topic based on the following specific themes:
- signaling via cell-cell communication
- genomic/epigenomic/proteomic approaches in cell communication research
- cross-talks of signaling molecules involved in cell motility
- regulation of podosome formation in healthy cells
- process of invadopodia formation of malignant cells
- molecular profiling of pathogenic cell communications
- protein-protein interactions regulating cell motility
We welcome review papers and original research studies on any of the suggested topics of cell-cell communication field.
Keywords: cell-cell communication, intercellular junctions, cross-talks of signaling molecules involved in cell motility, podosome, invadosome, invadopodia, genomic/epigenomic/proteomic approaches, protein-protein interactions regulating cell communications
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.