About this Research Topic
As the COVID-19 pandemic slows down, the SARS-CoV-2 virus keeps evolving into multiple variants. Individuals are still being reported to get infected with SARS-CoV-2 variants, such as omicron, even after multiple doses of vaccination. This is referred to as a breakthrough infection, and can be caused by inadequate or short-term immune responses following vaccination, as well as immune escape by the variants, due to antigen mismatch contributed by mutations in the new variants. Breakthrough infections can also be observed in the case of other virus infections, including Influenza.
Although the vaccines are updated every year to prevent disease severity in virus-infected individuals, the rate of viral transmission can still be high, causing long term consequences. Therefore, research focused on dissecting the underlying mechanisms of breakthrough infections is important to understand the direct implications of repeated vaccinations on consequent viral infections. To this end, we would like to invite research articles focused on vaccination and its correlation with virus transmissions in our Research Topic.
In this Research Topic, we welcome the submission of Original Research, Review and Mini Review articles with special emphasis on the following themes:
• Vaccine-mediated protection against viral challenge or re-challenge.
• The role of pre-existing antibodies in subsequent viral infections.
• The impact of memory B cells on vaccine efficacy and protection from viral infection/re-infection.
• The role of T cell immunity in virus infections and re-infections.
• Viral escape mechanisms in vaccinated individuals.
The Topic Editors declare no potential conflict of interest with regard to this Research Topic.
Although the vaccines are updated every year to prevent disease severity in virus-infected individuals, the rate of viral transmission can still be high, causing long term consequences. Therefore, research focused on dissecting the underlying mechanisms of breakthrough infections is important to understand the direct implications of repeated vaccinations on consequent viral infections. To this end, we would like to invite research articles focused on vaccination and its correlation with virus transmissions in our Research Topic.
In this Research Topic, we welcome the submission of Original Research, Review and Mini Review articles with special emphasis on the following themes:
• Vaccine-mediated protection against viral challenge or re-challenge.
• The role of pre-existing antibodies in subsequent viral infections.
• The impact of memory B cells on vaccine efficacy and protection from viral infection/re-infection.
• The role of T cell immunity in virus infections and re-infections.
• Viral escape mechanisms in vaccinated individuals.
The Topic Editors declare no potential conflict of interest with regard to this Research Topic.
Keywords: Vaccine, breakthrough infection, pre-existing immunity, SARS-CoV-2, influenza, infection, variants, immune escape
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
