Differentiating and understanding the multifaceted nature of Traumatic Brain Injury using clinical and pre-clinical systems

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About this Research Topic

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Background

Traumatic Brain Injury (TBI) is a complex neurological condition that arises from a multitude of causes, presents a vast range of symptoms, and requires diverse therapeutic approaches. Additionally, TBI involves an intricate interplay of physical, social, and psychological components such as cognitive, emotional well-being. The vast heterogeneity poses a significant challenge in clinical diagnosis, management, and intervention planning. This Research Topic focuses on advancing our understanding of the multifaceted nature of TBI, with an emphasis on differentiating between its various presentations, causes, and consequences to promote more precise diagnostics and targeted treatments. This may include pre-clinical studies including in vitro investigations underlying mechanisms of injury or clinical observational studies focusing on TBI outcome in real world situation.
We invite contributions from experts in neurology, neuropsychology, neuroimaging, rehabilitation, and other related disciplines. The Research Topic welcomes papers that examine the epidemiology of TBI, its variable etiology, the range of cognitive, behavioural, physical and emotional impacts, and tractable targets for therapeutic interventions. Submissions may include original research, literature reviews, methodological papers, and thematic analyses. This Research Topic aims to differentiate these components that are attributed to TBI thus enhancing our understanding of their distinct contributions and improving diagnostic accuracy and treatment planning for individuals with these co-occurring conditions.
Objectives:
1. Investigate the variable etiology of TBI: With causes ranging from vehicular accidents to sports injuries and falls, TBI is a complex condition with multiple sources. We invite research analyzing common and unusual etiologies, and the unique challenges each presents for prevention, diagnosis, and treatment.
2. Explore the multitude of TBI manifestations: TBI can result in a wide range of neurological deficits, cognitive impairments, psychological disorders, and physical disabilities. Detailed investigations into these diverse manifestations and their potential correlations will further our understanding of TBI’s complex symptomatology.
3. Evaluate current diagnostic and assessment tools: As the clinical presentation of TBI is highly variable, accurately diagnosing and classifying the severity of the condition poses a significant challenge. Research focusing on the assessment and diagnostic tools, including neuroimaging, neuropsychological testing, and neurobiochemical markers, is encouraged.
4. Investigate the impact of TBI on health and quality of life: Studies illuminating the long-term physical, psychological, cognitive, and socio-economic impacts of TBI will provide valuable insight into the condition’s implications for patients' quality of life and healthcare systems.
5. Review and develop treatment and rehabilitation strategies: Understanding the effectiveness of various therapeutic interventions and rehabilitation strategies for TBI is crucial. Rigorous reviews of present treatments, alongside innovative research to develop more tailored interventions and predictors of treatment outcomes, form a key part of this Research Topic.
Unpacking the multifaceted nature of TBI has substantial implications for improving diagnostic precision, refining treatment approaches, and enhancing patients' quality of life. By focusing on the diverse etiologies, manifestations, assessment tools, impacts, and treatments associated with TBI, this Research Topic aims at bridging the knowledge gaps and driving research forward to ultimately improve patient care and outcomes. We invite contributions from researchers in the fields of psychology, psychiatry, neurology, neuropsychology, and neuroscience. It focuses on investigating the physical, social, or psychological and cognitive components of TBI and aims to differentiate between their overlapping symptoms. Studies utilizing clinical assessments, neurocognitive testing, neuroimaging techniques, biomarker analysis and other objective measures are encouraged to enhance our understanding of the unique features of TBI.

Keywords: Neurological assessment, Symptomatology, Cognitive impairment, Rehabilitation strategies, Etiology differentiation, Neuroimaging, Neuropsychological testing, Physical disabilities, Psychological disorders, Therapeutic interventions

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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