About this Research Topic
Extracellular vesicles, comprising small and large vesicles, are integral messengers facilitating intercellular communication. Within embryogenesis, their role in temporal arrangement during critical developmental stages, and spatial cues for tissue patterning, comes to the forefront. These EV-mediated processes extend beyond embryogenesis, influencing stem cell fate decisions and contributing to tissue homeostasis in adult organisms. The molecular intricacies involve epigenetic modulation, integration with canonical developmental pathways, and the transformative impact of EV contents on cellular processes, shaping the organ-specific contributions to morphogenesis. As we scrutinize maternal-fetal communication and the neural landscape, we can see potential links between embryonic signaling pathways and cancer progression.
The goal of this Research Topic is to further our understanding of extracellular vesicle (EV) mediated cell signaling in the context of embryonic development and morphogenesis. A fundamental challenge lies in comprehending how EVs, particularly Large and Small EVs, orchestrate the temporal and spatial dynamics governing critical stages of embryogenesis. Investigating their role in transmitting molecular signals during early development, understanding their influence on tissue patterning, and deciphering their impact on stem cell fate decisions presents key challenges.
Recent advances in EV research, facilitated by cutting-edge technologies such as single-cell RNA sequencing and advanced imaging techniques, offer unprecedented insights. Exploring the molecular cargo within EVs and its dynamic changes during morphogenesis provides a foundation for understanding the transformative effects on cellular processes. Integrating this knowledge with canonical developmental pathways and discerning organ-specific contributions to morphogenesis remains a complex puzzle to solve.
Moreover, the exploration of EVs as potential messengers in cancer progression necessitates a deeper understanding of their role in recapitulating embryonic signaling pathways. By addressing these challenges and building upon recent advances, this Research Topic aims to not only expand our comprehension of fundamental biological processes but also unlock potential applications in disease biology and regenerative medicine.
We welcome submissions that focus on, but are not limited to, the following areas:
-How EVs identify molecular signals during critical embryonic stages.
-The role of EVs in providing spatial cues for tissue organization during morphogenesis.
-How EVs shape stem cell fate decisions, bridging the gap between embryogenesis and tissue homeostasis in adults.
-The involvement of EVs in epigenetic modifications, contributing to the regulatory landscape of developmental processes.
-The complex interplay between EV signaling and canonical developmental pathways, elucidating synergistic or antagonistic effects.
-The effects of EV contents on cellular processes, illuminating the molecular intricacies driving morphogenesis.
-The roles played by EVs in the formation and development of specific organs during embryogenesis.
-The molecular dialogues facilitated by EVs in the communication between maternal and fetal tissues during embryonic development.
-The influence of EVs, spanning embryonic origins to the intricate network of synaptic connections in neural development.
-Investigate potential connections between embryonic signaling pathways carried by EVs and their role in adulthood cancer progression.
The goal of this Research Topic is to further our understanding of extracellular vesicle (EV) mediated cell signaling in the context of embryonic development and morphogenesis. A fundamental challenge lies in comprehending how EVs, particularly Large and Small EVs, orchestrate the temporal and spatial dynamics governing critical stages of embryogenesis. Investigating their role in transmitting molecular signals during early development, understanding their influence on tissue patterning, and deciphering their impact on stem cell fate decisions presents key challenges.
Recent advances in EV research, facilitated by cutting-edge technologies such as single-cell RNA sequencing and advanced imaging techniques, offer unprecedented insights. Exploring the molecular cargo within EVs and its dynamic changes during morphogenesis provides a foundation for understanding the transformative effects on cellular processes. Integrating this knowledge with canonical developmental pathways and discerning organ-specific contributions to morphogenesis remains a complex puzzle to solve.
Moreover, the exploration of EVs as potential messengers in cancer progression necessitates a deeper understanding of their role in recapitulating embryonic signaling pathways. By addressing these challenges and building upon recent advances, this Research Topic aims to not only expand our comprehension of fundamental biological processes but also unlock potential applications in disease biology and regenerative medicine.
We welcome submissions that focus on, but are not limited to, the following areas:
-How EVs identify molecular signals during critical embryonic stages.
-The role of EVs in providing spatial cues for tissue organization during morphogenesis.
-How EVs shape stem cell fate decisions, bridging the gap between embryogenesis and tissue homeostasis in adults.
-The involvement of EVs in epigenetic modifications, contributing to the regulatory landscape of developmental processes.
-The complex interplay between EV signaling and canonical developmental pathways, elucidating synergistic or antagonistic effects.
-The effects of EV contents on cellular processes, illuminating the molecular intricacies driving morphogenesis.
-The roles played by EVs in the formation and development of specific organs during embryogenesis.
-The molecular dialogues facilitated by EVs in the communication between maternal and fetal tissues during embryonic development.
-The influence of EVs, spanning embryonic origins to the intricate network of synaptic connections in neural development.
-Investigate potential connections between embryonic signaling pathways carried by EVs and their role in adulthood cancer progression.
Keywords: Extracellular vesicles, Embryogenesis to Morphogenesis, Embryogenic genes in Cancer
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
