Frontiers | Beyond Borders: Exploring Diverse Roles of Heterocyclic Compounds in Combatting Infections and Cancer

Beyond Borders: Exploring Diverse Roles of Heterocyclic Compounds in Combatting Infections and Cancer

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ORIGINAL RESEARCH

Accepted on 21 Jan 2025

Therapeutic Potential of Laurus nobilis Extract by Experimental and Computational Approaches: Phenolic Content and Bioactivities for Antioxidant, Antidiabetic, and Anticholinergic Properties

Sevgi Altın
Mesut Işık
Cemalettin Alp
Emrah Dikici
Ekrem Köksal
Kevser Kübra Kırboğa
Mithun Rudrapal
Gourav Rakshit
Şükrü Beydemir
Johra Khan

doi 10.3389/fchem.2025.1541250

ORIGINAL RESEARCH

Published on 16 Jan 2025

Exploring the potential of some natural indoles as antiviral agents: quantum chemical analysis, inverse molecular docking, and affinity calculations

Amany Belal
Aly Abdou
Samar F. Miski
Mohamed A. M. Ali
Heba I. Ghamry
Ahmad J. Obaidullah
Mohamed Y. Zaky
Ahmed H. E. Hassan
Eun Joo Roh
1 more
Mona H. Ibrahim

doi 10.3389/fchem.2024.1521298

380 views

ORIGINAL RESEARCH

Published on 15 Jan 2025

Syzygium aromaticum extract mediated, sustainable silver nanoparticle synergetic with heterocyclic antibiotic clarithromycin and their antimicrobial activities

Zehra Edis
Samir Haj Bloukh
Akram A. Ashames
Moawia M. Al-Tabakha
Moyad J. S. A. Shahwan
Hamed Abu Sara
Sai H. S. Boddu
Sohaib N. Khan
Ibrahim Haj Bloukh
4 more
Nageeb A. G. M. Hassan

doi 10.3389/fchem.2024.1513150

478 views

ORIGINAL RESEARCH

Published on 06 Jan 2025

Exploring the antifungal potential of Cannabis sativa-derived stilbenoids and cannabinoids against novel targets through in silico protein interaction profiling

Kevser Kübra Kırboğa
Aman Karim
Ecir Uğur Küçüksille
Mithun Rudrapal
Johra Khan
Raghu Ram Achar
Ekaterina Silina
Natalia Manturova
Victor Stupin

doi 10.3389/fchem.2024.1515424

359 views

ORIGINAL RESEARCH

Published on 13 Dec 2024

Lotus seed (Nelumbinis semen) extract: anticancer potential and chemoprofiling by in vitro, in silico and GC-MS studies

Vijaya Jyothi Mallela
Mithun Rudrapal
D. S. N. B. K. Prasanth
Praveen Kumar Pasala
Atul R. Bendale
Soumya Bhattacharya
Sahar M. Aldosari
Johra Khan

doi 10.3389/fchem.2024.1505272

639 views

ORIGINAL RESEARCH

Published on 12 Nov 2024

Synthesis, enzyme inhibition, and docking studies of new schiff bases of disalicylic acid methylene-based derivatives as dual-target antibacterial agents

Lamya H. Al-Wahaibi
Mohamed A. Mahmoud
Hayat Ali Alzahrani
Hesham A. Abou-Zied
Alshaimaa Abdelmoez
Bahaa G. M. Youssif
Stefan Bräse
Safwat M. Rabea

doi 10.3389/fchem.2024.1493906

490 views

ORIGINAL RESEARCH

Published on 16 Oct 2024

Synthesis and antibacterial potential of novel thymol derivatives against methicillin-resistant Staphylococcus aureus and P. aeruginosa pathogenic bacteria

Ashutosh Shahi
Rakshit Manhas
Srija Bhattacharya
Arti Rathore
Puneet Kumar
Jayanta Samanta
Manish Kumar Sharma
Avisek Mahapa
Prasoon Gupta
Jasha Momo H. Anal

doi 10.3389/fchem.2024.1482852

918 views

ORIGINAL RESEARCH

Published on 15 Oct 2024

Sustainable synthesis of silver nanoparticles from Azadirachta indica: antimicrobial, antioxidant and in silico analysis for periodontal treatment

Binapani Barik
Bhabani Sankar Satapathy
Gurudutta Pattnaik
Desai Vijay Bhavrao
Krishna Prasad Shetty

doi 10.3389/fchem.2024.1489253

754 views

ORIGINAL RESEARCH

Published on 07 Aug 2024

Identification of 2-(N-aryl-1,2,3-triazol-4-yl) quinoline derivatives as antitubercular agents endowed with InhA inhibitory activity

Ahmed Sabt
Maha-Hamadien Abdulla
Manal S. Ebaid
Jakub Pawełczyk
Hayam A. Abd El Salam
Ninh The Son
Nguyen Xuan Ha
Mansoor-Ali Vaali Mohammed
Thamer Traiki
3 more
Wagdy M. Eldehna

doi 10.3389/fchem.2024.1424017

1,242 views
1 citation

ORIGINAL RESEARCH

Published on 06 Aug 2024

Exploring novel Apalutamide analogues as potential therapeutics for prostate cancer: design, molecular docking investigations and molecular dynamics simulation

Ajay Kumar Gupta
Yogesh Vaishnav
Sanmati Kumar Jain
Sivakumar Annadurai
Neeraj Kumar

doi 10.3389/fchem.2024.1418975

1,000 views

ORIGINAL RESEARCH

Published on 03 Jul 2024

Discovery and prospects of new heterocyclic Isatin-hydrazide derivative with a novel role as estrogen receptor α degrader in breast cancer cells

Muhammad Nouman Arif
Sadia Sarwar
Farhat Firdous
Rahman Shah Zaib Saleem
Humaira Nadeem
Abir Abdullah Alamro
Amani Ahmad Alghamdi
Atekah Hazza Alshammari
Omer Farooq
1 more
Amir Faisal

doi 10.3389/fchem.2024.1424637

2,483 views
1 citation

ORIGINAL RESEARCH

Published on 27 May 2024

Synthesis and biological evaluation of chrysin derivatives containing α-lipoic acid for the treatment of inflammatory bowel disease

Pengyu Zhao
Yusen Hou
Tingting Yan
Jie Kang
Ye Tian
Jiaxin Li
Chenjuan Zeng
Funeng Geng
Qi Liao

doi 10.3389/fchem.2024.1406051

770 views

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Articles

Therapeutic Potential of Laurus nobilis Extract by Experimental and Computational Approaches: Phenolic Content and Bioactivities for Antioxidant, Antidiabetic, and Anticholinergic Properties

Exploring the potential of some natural indoles as antiviral agents: quantum chemical analysis, inverse molecular docking, and affinity calculations

Syzygium aromaticum extract mediated, sustainable silver nanoparticle synergetic with heterocyclic antibiotic clarithromycin and their antimicrobial activities

Exploring the antifungal potential of Cannabis sativa-derived stilbenoids and cannabinoids against novel targets through in silico protein interaction profiling

Lotus seed (Nelumbinis semen) extract: anticancer potential and chemoprofiling by in vitro, in silico and GC-MS studies

Synthesis, enzyme inhibition, and docking studies of new schiff bases of disalicylic acid methylene-based derivatives as dual-target antibacterial agents

Synthesis and antibacterial potential of novel thymol derivatives against methicillin-resistant Staphylococcus aureus and P. aeruginosa pathogenic bacteria

Sustainable synthesis of silver nanoparticles from Azadirachta indica: antimicrobial, antioxidant and in silico analysis for periodontal treatment

Identification of 2-(N-aryl-1,2,3-triazol-4-yl) quinoline derivatives as antitubercular agents endowed with InhA inhibitory activity

Exploring novel Apalutamide analogues as potential therapeutics for prostate cancer: design, molecular docking investigations and molecular dynamics simulation

Discovery and prospects of new heterocyclic Isatin-hydrazide derivative with a novel role as estrogen receptor α degrader in breast cancer cells

Synthesis and biological evaluation of chrysin derivatives containing α-lipoic acid for the treatment of inflammatory bowel disease

Frontiers in Chemistry

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