About this Research Topic
The calcium ion (Ca2+) plays a fundamental role in a number of physiological functions including bone formation, muscle contraction, secretion, enzyme cofactor, stabilization of membrane potentials, and blood coagulation. Calcium is homeostatically regulated by hormones that determine calcium balance within the body.
Calcium signaling pathways also regulate gene expression and cardiomyocyte growth during development and pathology. These fundamental roles of calcium in the heart are illustrated by the prevalence of altered calcium homeostasis in cardiovascular disease. Therefore, the identity of calcium signaling modification strategies is an important target for the development of therapeutic approaches for cardiovascular diseases.
The complex relationship between hormones, calcium homeostasis/signaling, and the health of the cardiovascular system emphasizes the multifaceted nature of the pathogenesis of cardiovascular diseases. The purpose of this Research Topic is to discuss the relationship between hormones, calcium homeostasis/signaling and cardiovascular disease, and the potential interference by improving the quality of calcium regulation to alleviate cardiovascular disease.
This Research Topic welcomes original research articles, mini reviews, and systematic reviews on themes related to:
- The mechanism of calcium homeostasis disturbances by hormones in cardiovascular diseases and interventions to stabilize calcium homeostasis;
- The potential role of calcium signaling pathway on cardiovascular diseases;
- The effects of persistent genomic and/or mitochondrial DNA damage on cardiovascular diseases;
- The possible mechanism via calcium signaling pathways to cardiovascular disease progression;
- Underlying mechanisms of inducing calcium-binding proteins on endoplasmic reticulum or mitochondria during the occurrence and development of cardiovascular diseases;
Keywords: calcium-binding proteins, mitochondria, heart failure, cardiovascular disease, ryanodine receptor, immune response, inflammation, neutrophil
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