The Mechanism in Gut Microbiota of Diabetes and Endocrine Complications: Preventive and Therapeutic Target

In recent years, growing attention has been allocated to the relationship between the gut microbiome and disease, especially the complex relationship between diabetes and endocrine complications. The gut microbiota is one of the most complex microbial communities and has formed a close symbiotic relationship with its host in a long period of co-evolution. Beneficial bacteria can produce a variety of bioactive substances and participate in host nutrition, metabolism, immunity and behavioral regulation by regulating host gene expression. Hence, the role of gut microbiota, which is ecologically dominated by beneficial bacteria, as a ‘second genome’ in maintaining human homeostasis has attracted more and more attention in recent years. On the other hand, many opportunistic pathogens and miscellaneous bacteria can produce toxic metabolites lurking in the gut, and the dysbacteria can lead to insulin resistance and inflammation, which may disrupt the metabolic balance of the host. Changing the microbiome structure through lifestyle interventions, medications, and fecal microbiota transplantation can be beneficial for disease-related phenotypes. Therefore, understanding the subtle interactions within the microbiome is crucial for deciphering the complex pathogenesis of diabetes and endocrine complications.

This Research Topic aims to explore the multifaceted functions of the microbiota, delving into its role in metabolic health and the intricate mechanisms by which it influences diabetes and associated complications. By identifying specific microbial contributions, we seek to unlock novel preventive and therapeutic targets, presenting a frontier for transformative discoveries in the field of endocrinology.

Potential sub-topics include but are not limited to the following:
● Determine novel signal molecules that take part in the development of diabetes and endocrine complications
● Investigate the effects and mechanisms in different bacterial communities on diabetes subtypes
● Discover gut microbiota-related metabolite biomarkers for the diagnosis or prognosis of diabetes and endocrine complications
● Explore the effect of gut microbiota modulation (such as pre/probiotics, microbiota transplantation, medication use, and lifestyle changes) on diabetes and endocrine complications.
● Find the clinical implications of targeting gut microbiota and its metabolism in diabetes and endocrine complications
● Conduct functional study of metabolites/peptides during the occurrence and development of diabetes.