Inflammation and Immune Factors in Venous Thromboembolism

  • 1,584

    Total downloads

  • 5,373

    Total views and downloads

Submit your idea

You will be redirected to our submission process.

Submit your manuscript summarySubmit your manuscript

About this Research Topic

Background

Venous thromboembolism (VTE), comprising deep vein thrombosis and pulmonary embolism, is a major cause of morbidity and mortality worldwide. There is increasing evidence that inflammation and immunological factors play an important role in the pathogenesis of VTE. Alteration of blood flow by surgery, trauma, or prolonged immobility triggers an inflammatory response, mediated by activation of multiple inflammatory pathways, and recruitment of immune cells such as neutrophils, monocytes, and platelets. These factors converge on the endothelium, changing its phenotype from antithrombotic to prothrombotic, which eventually culminates in thrombus formation. A growing number of immune system components are involved in venous thrombosis including neutrophil extracellular traps, complement pathways, inflammasomes among many others. As most immune factors are not directly involved in normal hemostasis, targeting of this pathway could efficiently prevent thrombosis while avoiding bleeding complications. Understanding the inflammatory and immunological mechanisms involved in VTE is key for developing better diagnostic, prevention, and treatment strategies.

The goal of this Research Topic is to highlight recent research that sheds light on the intricate roles that inflammation and immunity play in venous thromboembolism (VTE). We aim to publish innovative research covering this rapidly expanding area from both established leaders and emerging pioneers in the field. By compiling evidence from human translational studies, animal models, and fundamental science at the intersection of multiple disciplines, this issue seeks to accelerate advances in our collective understanding of VTE pathophysiology. Additionally, we hope to reveal promising new directions, techniques, and therapeutic strategies that may one day translate to improved patient outcomes. Overall, this issue strives to energize and empower researchers to embrace immunology and inflammation as pivotal new frontiers in the quest to better prevent, diagnose, predict, and treat VTE - the leading cause of preventable hospital death. Research in this niche domain promises clinical breakthroughs in ameliorating this disease’s substantial worldwide burden.

Research aiming at delineating immune mechanisms of VTE is ongoing globally, yet our understanding of the role of inflammation in its pathogenesis remains incomplete. The list of open research question includes, but is not limited to, the interplay between inflammation, immunological processes, immune cells, and coagulation in promoting thrombosis. Our knowledge on these key areas remains limited. The role of vascular endothelial cells in promoting localized inflammation and coagulation through expression of adhesion molecules, cytokines, and coagulation factors should be further elucidated. A better understanding of endothelial involvement may lead to new therapeutic targets. State-of the art techniques, including genomics, proteomic and single-cell sequencing approaches, are primed to identify novel inflammatory/immunological therapeutic targets in VTE. Development of novel imaging techniques to allow in vivo visualization of immune cell infiltration, endothelial dysfunction, and inflammation could significantly aid diagnosis and treatment decisions. Further, machine learning approaches can be employed to integrate clinical, genetic, immune, and coagulation biomarkers into predictive models for VTE risk stratification. Finally, the role of inflammation in chronic thrombosis resolution also remains an important facet awaiting further investigation. Filling all these gaps in knowledge would pave the way to developing more effective strategies for preventing and treating VTE.

This special issue aims to showcase high-quality original research that furthers understanding of the interplay between inflammatory and immunological pathways in the pathogenesis of VTE. We welcome submissions focusing on, but not limited to:
• Characterization of inflammatory cells, cytokines, biomarkers in VTE
• Roles of immune cell extracellular traps (NETs, EETs) in thrombosis
• Endothelial cell activation and microvascular dysfunction
• Autoantibodies, complement networks, platelets, and VTE
• Immune-coagulation protein interactions and VTE
• Influence of innate and adaptive immunity on VTE
• Role of microbiota in VTE
• Inflammation and immune system in VTE resolution
• Novel imaging tracking neuroinflammation and immunothrombosis
• Targeting inflammation and immunity for VTE prevention and treatment

Additional aspects relating immunity and inflammation to thrombosis, thrombophilia, or fibrinolysis will be considered. Translational and clinical studies in humans as well as fundamental and preclinical research are highly sought. Authors should highlight implications for better understanding VTE pathophysiology as well as future diagnostic or therapeutic innovations.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

  • Brief Research Report
  • Case Report
  • Classification
  • Clinical Trial
  • Editorial
  • General Commentary
  • Hypothesis and Theory
  • Methods
  • Mini Review

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

  • Brief Research Report
  • Case Report
  • Classification
  • Clinical Trial
  • Editorial
  • General Commentary
  • Hypothesis and Theory
  • Methods
  • Mini Review
  • Opinion
  • Original Research
  • Perspective
  • Review
  • Study Protocol
  • Systematic Review
  • Technology and Code

Keywords: Venous thromboembolism, deep vein thrombosis, immunity, inflammation, neutrophils, endothelial cells, cytokines, Extracellular Traps, inflammasome, platelets

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Topic editors

Frequently asked questions

  • Frontiers' Research Topics are collaborative hubs built around an emerging theme.Defined, managed, and led by renowned researchers, they bring communities together around a shared area of interest to stimulate collaboration and innovation.

    Unlike section journals, which serve established specialty communities, Research Topics are pioneer hubs, responding to the evolving scientific landscape and catering to new communities.

  • The goal of Frontiers' publishing program is to empower research communities to actively steer the course of scientific publishing. Our program was implemented as a three-part unit with fixed field journals, flexible specialty sections, and dynamically emerging Research Topics, connecting communities of different sizes and maturity.

    Research Topics originate from the scientific community. Many of our Research Topics are suggested by existing editorial board members who have identified critical challenges or areas of interest in their field.

  • As an editor, Research Topics will help you build your journal, as well as your community, around emerging, cutting-edge research. As research trailblazers, Research Topics attract high-quality submissions from leading experts all over the world.

    A thriving Research Topic can potentially evolve into a new specialty section if there is sustained interest and a growing community around it.

  • Each Research Topic must be approved by the specialty chief editor, and it falls under the editorial oversight of our editorial boards, supported by our in-house research integrity team. The same standards and rigorous peer review processes apply to articles published as part of a Research Topic as for any other article we publish.

    In 2023, 80% of the Research Topics we published were edited or co-edited by our editorial board members, who are already familiar with their journal's scope, ethos, and publishing model. All other topics are guest edited by leaders in their field, each vetted and formally approved by the specialty chief editor.

  • Publishing your article within a Research Topic with other related articles increases its discoverability and visibility, which can lead to more views, downloads, and citations. Research Topics grow dynamically as more published articles are added, causing frequent revisiting, and further visibility.

    As Research Topics are multidisciplinary, they are cross-listed in several fields and section journals – increasing your reach even more and giving you the chance to expand your network and collaborate with researchers in different fields, all focusing on expanding knowledge around the same important topic.

    Our larger Research Topics are also converted into ebooks and receive social media promotion from our digital marketing team.

     

  • Frontiers offers multiple article types, but it will depend on the field and section journals in which the Research Topic will be featured. The available article types for a Research Topic will appear in the drop-down menu during the submission process.

    Check available article types here 

  • Yes, we would love to hear your ideas for a topic. Most of our Research Topics are community-led and suggested by researchers in the field. Our in-house editorial team will contact you to talk about your idea and whether you’d like to edit the topic. If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. 

    Suggest your topic here 

  • A team of guest editors (called topic editors) lead their Research Topic. This editorial team oversees the entire process, from the initial topic proposal to calls for participation, the peer review, and final publications.

    The team may also include topic coordinators, who help the topic editors send calls for participation, liaise with topic editors on abstracts, and support contributing authors. In some cases, they can also be assigned as reviewers.

  • As a topic editor (TE), you will take the lead on all editorial decisions for the Research Topic, starting with defining its scope. This allows you to curate research around a topic that interests you, bring together different perspectives from leading researchers across different fields and shape the future of your field. 

     

    You will choose your team of co-editors, curate a list of potential authors, send calls for participation and oversee the peer review process, accepting or recommending rejection for each manuscript submitted.

  • As a topic editor, you're supported at every stage by our in-house team. You will be assigned a single point of contact to help you on both editorial and technical matters. Your topic is managed through our user-friendly online platform, and the peer review process is supported by our industry-first AI review assistant (AIRA).

  • If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. This provides you with valuable editorial experience, improving your ability to critically evaluate research articles and enhancing your understanding of the quality standards and requirements for scientific publishing, as well as the opportunity to discover new research in your field, and expand your professional network.

  • Yes, certificates can be issued on request. We are happy to provide a certificate for your contribution to editing a successful Research Topic.

  • Research Topics thrive on collaboration and their multi-disciplinary approach around emerging, cutting-edge themes, attract leading researchers from all over the world.

  • As a topic editor, you can set the timeline for your Research Topic, and we will work with you at your pace. Typically, Research Topics are online and open for submissions within a few weeks and remain open for participation for 6 – 12 months. Individual articles within a Research Topic are published as soon as they are ready.

    Find out more about our Research Topics

  • Our fee support program ensures that all articles that pass peer review, including those published in Research Topics, can benefit from open access – regardless of the author's field or funding situation.

    Authors and institutions with insufficient funding can apply for a discount on their publishing fees. A fee support application form is available on our website.

  • In line with our mission to promote healthy lives on a healthy planet, we do not provide printed materials. All our articles and ebooks are available under a CC-BY license, so you can share and print copies.

     

Manuscripts can be submitted to this Research Topic via the main journal or any other participating journal.

Submit your idea

You will be redirected to our submission process.

Submit your manuscript summarySubmit your manuscript

Impact

  • 5,373Topic views
  • 3,151Article views
  • 1,584Article downloads
View impact