About this Research Topic
Non-coding RNAs (ncRNAs) have gained recognition as significant modulators of gene expression and cellular mechanisms, encompassing cholesterol homeostasis. The disruption of cholesterol homeostasis plays a substantial role in the progression of atherosclerosis and cardiovascular ailments. MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) have been identified as pivotal regulators of cholesterol biosynthesis and have been implicated in the etiology of these pathological conditions. The manipulation of these disease-associated ncRNAs presents novel avenues for the prevention and treatment of atherosclerosis and associated cardiovascular diseases. In summary, the investigation of ncRNAs in the maintenance of cholesterol homeostasis has unveiled their substantial involvement in the regulation of cholesterol synthesis, removal, lipid droplet function, and the development of lipid-related diseases. Subsequent research endeavors in this domain will probably concentrate on the identification of novel ncRNAs, understanding their mechanisms of operation, and investigating their potential therapeutic applications in the management of disorders related to cholesterol.
This Research Topic aims to establish a platform for discussing recent advancements and future prospects concerning cholesterol homeostasis and the aberrant expression of non-coding RNA mechanisms that connect cholesterol efflux and reverse cholesterol transport, metabolic syndrome, and cardiovascular disease (CVD). Additionally, it seeks to explore the pathophysiological and clinical ramifications of CVD resulting from disrupted cholesterol levels, lipid droplet formation, and lipid metabolism.
We welcome submissions on the following topics, but are not limited to:
- Regulation of Cholesterol Biosynthesis.
- Cholesterol Efflux and Reverse Cholesterol Transport.
- Lipid Droplet Formation and Lipid Metabolism.
- Atherosclerosis and Cardiovascular Diseases.
- Therapeutic Potential of ncRNAs.
This Research Topic aims to establish a platform for discussing recent advancements and future prospects concerning cholesterol homeostasis and the aberrant expression of non-coding RNA mechanisms that connect cholesterol efflux and reverse cholesterol transport, metabolic syndrome, and cardiovascular disease (CVD). Additionally, it seeks to explore the pathophysiological and clinical ramifications of CVD resulting from disrupted cholesterol levels, lipid droplet formation, and lipid metabolism.
We welcome submissions on the following topics, but are not limited to:
- Regulation of Cholesterol Biosynthesis.
- Cholesterol Efflux and Reverse Cholesterol Transport.
- Lipid Droplet Formation and Lipid Metabolism.
- Atherosclerosis and Cardiovascular Diseases.
- Therapeutic Potential of ncRNAs.
Keywords: cholesterol homeostasis, ncRNAs, biomarkers, lipid droplet formation, lipid metabolism, cardiovascular diseases
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
