About this Research Topic

Background

Everybody's experience of aging is unique; however, several aging indicators are deemed "premature" if they appear before the age of 35. A complex process, premature aging is influenced by several variables, including genetics, diabetes, early menarche, early menopause, nulliparity, chronic stress, malnutrition, and mental health issues. Premature aging syndromes also referred to as progeria, are comprised of two extremely rare inherited conditions: Hutchinson-Gilford syndrome and Werner syndrome. Progeria is a condition caused by a mutation in the LMNA gene, which codes for the lamin A protein. Lamin A protein acts as a scaffolding that holds the cell's nucleus together. Researchers have discovered that the faulty lamin A protein causes the nucleus to become unstable, leading to cellular instability, which in turn triggers the process of premature aging in progeria. Affected children develop all of the external signs of old age, including baldness, hunched posture, and dry, inelastic, and wrinkled skin.

While aging is something you cannot halt, you can prevent it from happening too soon. This compilation focuses on the reproductive, cardiovascular, cellular, genetic, lifestyle, environmental, and immunological aspects of premature aging. Here, we will explore about the progression of the relevant diseases, prognosis, and prevention to reduce the prevalence of neurological disorders, diseases, and aging-related impairments. These may help us identify various therapy targets that could either prevent or mitigate a patient's symptoms of premature aging.

We invite original research, reviews, or case studies that elucidate the mechanisms, pathophysiology, strategies for prevention, and therapeutic approaches for premature aging. We welcome submissions that cover (but are not limited to) the following points.

•The goal of premature aging research is to understand the pathophysiology of premature aging disorders, create novel treatment techniques, and gain insights into physiological aging processes.
•To understand the underlying mechanisms and risk factors linked with premature aging, as well as to develop appropriate preventive strategies and therapies.
•Understanding the mechanisms of premature aging, including telomeres and telomerase, DNA damage and repair deficiencies, and aberrant mineral ion homeostasis.
•Premature aging has also been linked to disorders like type 2 diabetes, autoimmune diseases, and metabolic bone disease. It is critical to develop tailored interventions and improve health outcomes by considering genetic, environmental, and lifestyle factors.
•Previously, researchers investigated the significance of gut microbiome remodeling in the prevention of premature aging. It will also be necessary to concentrate on these paths.
•To learn more about the possible link between premature aging and the onset of puberty. Previous research has shown that, in contrast to normal aging, the ovaries and testes become inactive during premature aging, resulting in sterility. Females do not have menstrual cycles.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Data Report
• Editorial
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Data Report
• Editorial
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Systematic Review
• Technology and Code

Keywords: Premature aging, Mechanisms, Pathophysiology, Prevention, and Therapies

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