Plant-derived Therapeutics and Traditional Medicine: Innovations, Challenges, and Opportunities in Breast Cancer Treatment

  • 593

    Total downloads

  • 2,657

    Total views and downloads

About this Research Topic

Submission deadlines

  1. Manuscript Submission Deadline 31 January 2025

  2. This Research Topic is still accepting articles.

Background

Breast cancer, widely recognized as the leading and most varied malignancy in women worldwide, poses significant healthcare challenges. Contemporary anticancer strategies using biomedical approaches incorporate surgery, chemotherapy, targeted, and endocrine therapy. Nonetheless, these strategies often depict a host of limitations, encompassing postoperative complications, recurrences and metastases, & numerous side-effects. Further exacerbating the issue, drug resistance often leads to breast cancer treatments becoming ineffective.

Several groundbreaking studies on breast cancer have recently highlighted the value of multi-target drug development. Phytochemicals, with paclitaxel as a notable and well established example, have demonstrated considerable antitumor potential, which has inspired their development into anticancer pharmaceuticals. This stimulus for anti-cancer pharmaceutical development is largely due to paclitaxel's pharmacological effects both in vitro and in vivo and the subsequent clinical studies. In in vitro studies, paclitaxel promotes the assembly of microtubules from tubulin dimers and stabilizes microtubules by preventing depolymerization, thereby inhibiting the normal dynamic reorganization of the microtubule network required for vital interphase and mitotic cellular functions. These cellular disruptions trigger programmed cell death or apoptosis. In vivo, aside from its cytotoxic effects on tumor cells, paclitaxel also has anti-angiogenic properties that hinder the growth of new blood vessels necessary for tumors to grow and metastasize, therefore exerting a broader therapeutic effect against cancer.

Concurrently, the many traditional systems globally have made important contributions to breast cancer treatment and to managing symptoms. While the topic puts a strong emphasis on Traditional Chinese Medicine (TCM), the research topic is open for submissions investigating preparations from many medical tradition.

TCM, for example, based on a complex philosophical background and a strong empirical basis in treating breast cancer, offers opportunities for adjuvant treatments as well as for drug discovery strategies. Systematic observations and detailed pharmacological experiments concerning possible drug targets and drug mechanisms have proven certain classic Chinese medicine formulas and TCM-derived chemical compounds to hold promise in breast cancer therapy and prevention. Highlighting its multi-target engagement, TCM has emerged as an important player in cancer therapeutics. Pharmacological approaches are crucial to identifying and evaluating the potential of TCM preparations or TCM-derived single metabolites and their semi-synthetic derivatives as therapeutics. Innovations in computational approaches, large-scale screening techniques, and the advent of artificial intelligence technologies offer promising avenues to unlock the potential of natural medicines.

Despite the significant research currently being conducted in the field of plant-derived anti-cancer agents, there is a lack of translational research, in order to develop outcomes at the discovery phase to the development of clinically viable treatments. These obstacles include hurdles in preclinical development, pharmacokinetic and pharmacodynamic issues, as well as difficulties related to clinical trial design and implementation. The mechanisms of action of plant-derived metabolites are often not fully understood, and issues such as poor solubility and low membrane permeability can hinder progress. There are challenges related to the variability in the quality and consistency of natural compounds, scalability of production, intellectual property issues, and regulatory hurdles. There also remain important challenges in terms of experimental reproducibility and applicability. Consequently, there remains a significant gap in the advancement stages of the pipeline for these potential treatments.

This research topic offers a platform to discuss recent advancements in the identification, assessment, and development of TCM-drugs, or metabolites derived from these, as potential treatments for breast cancer, and to identify future research directions and opportunities. We are appreciative of submissions covering, but not limited to, the following areas:

• Pharmacological approaches to drug discovery for breast-cancer and related diseases, including breast cancer as such, breast cystic hyperplasia, and breast fibroadenoma, using TCM-preparations, or metabolites derived from them. This may include the use of AI technology or computational approaches in potential drug discovery or design if (!) these are combined with pharmacological (experimental) approaches.

• Identification, characterization, and optimization of herbal medicinal products derived from any medical tradition globally for breast cancer

• Studies of the anti-cancer effect and mechanisms of preparations used traditionally in the (adjuvant) treatment of breast cancer and metabolites derived from them, including in vivo studies and clinical research.

• Studies focusing on overcoming the barriers in the development of initial leads into therapeutically relevant medications. This includes their biopharmaceutical characteristics, such as overcoming low solubility or limited membrane permeability, Therefore, submissions may also incorporate studies to augment these attributes or research on novel drug delivery systems.

• Combination therapies employing commercial herbal medical products for treating breast cancer.

• As the regulation of immune responses has been proven effective in combating tumors, we also welcome investigations based on the tumor immune microenvironment (TIME), particularly those focusing on the regulatory mechanisms influenced by TCM.

Important Note:

All contributions to this Research Topic must follow the guideline listed in this section:
• The introduction should describe the background of the research object and provide bibliographical references that illustrate its recent application in general healthcare.
• Research-baseded solely on in silico approaches (e.g., network studies or docking experiments) does not fit with the scopes of this SI.
• Small molecules exhibiting in silico or in vitro effects but without specific pharmacological targets do not fit with the scopes of this SI.
• Chemical anti-oxidant assays like the DPPH or ABTS assay are of no pharmacological relevance, Therefore they can only be used a chemical-analytical assays without pharmacological claims.
• Please self-assess your MS using the ConPhyMP tool, and follow the standards established in the ConPhyMP statement Front. Pharmacol. 13:953205. All the manuscripts need to fully comply with the Four Pillars of Best Practice in Ethnopharmacology (you can freely download the full version here). Importantly, please ascertain that the ethnopharmacological context is clearly described (pillar 3d) and that the material investigated is characterized in detail (pillars 2 a and b).

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

  • Brief Research Report
  • Case Report
  • Clinical Trial
  • Data Report
  • Editorial
  • General Commentary
  • Hypothesis and Theory
  • Methods
  • Mini Review

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Keywords: Herbal medicine, Natural products, Mechanism, Breast cancer, Drug delivery

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Frequently asked questions

  • Frontiers' Research Topics are collaborative hubs built around an emerging theme.Defined, managed, and led by renowned researchers, they bring communities together around a shared area of interest to stimulate collaboration and innovation.

    Unlike section journals, which serve established specialty communities, Research Topics are pioneer hubs, responding to the evolving scientific landscape and catering to new communities.

  • The goal of Frontiers' publishing program is to empower research communities to actively steer the course of scientific publishing. Our program was implemented as a three-part unit with fixed field journals, flexible specialty sections, and dynamically emerging Research Topics, connecting communities of different sizes and maturity.

    Research Topics originate from the scientific community. Many of our Research Topics are suggested by existing editorial board members who have identified critical challenges or areas of interest in their field.

  • As an editor, Research Topics will help you build your journal, as well as your community, around emerging, cutting-edge research. As research trailblazers, Research Topics attract high-quality submissions from leading experts all over the world.

    A thriving Research Topic can potentially evolve into a new specialty section if there is sustained interest and a growing community around it.

  • Each Research Topic must be approved by the specialty chief editor, and it falls under the editorial oversight of our editorial boards, supported by our in-house research integrity team. The same standards and rigorous peer review processes apply to articles published as part of a Research Topic as for any other article we publish.

    In 2023, 80% of the Research Topics we published were edited or co-edited by our editorial board members, who are already familiar with their journal's scope, ethos, and publishing model. All other topics are guest edited by leaders in their field, each vetted and formally approved by the specialty chief editor.

  • Publishing your article within a Research Topic with other related articles increases its discoverability and visibility, which can lead to more views, downloads, and citations. Research Topics grow dynamically as more published articles are added, causing frequent revisiting, and further visibility.

    As Research Topics are multidisciplinary, they are cross-listed in several fields and section journals – increasing your reach even more and giving you the chance to expand your network and collaborate with researchers in different fields, all focusing on expanding knowledge around the same important topic.

    Our larger Research Topics are also converted into ebooks and receive social media promotion from our digital marketing team.

  • Frontiers offers multiple article types, but it will depend on the field and section journals in which the Research Topic will be featured. The available article types for a Research Topic will appear in the drop-down menu during the submission process.

    Check available article types here 

  • Yes, we would love to hear your ideas for a topic. Most of our Research Topics are community-led and suggested by researchers in the field. Our in-house editorial team will contact you to talk about your idea and whether you’d like to edit the topic. If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. 

    Suggest your topic here 

  • A team of guest editors (called topic editors) lead their Research Topic. This editorial team oversees the entire process, from the initial topic proposal to calls for participation, the peer review, and final publications.

    The team may also include topic coordinators, who help the topic editors send calls for participation, liaise with topic editors on abstracts, and support contributing authors. In some cases, they can also be assigned as reviewers.

  • As a topic editor (TE), you will take the lead on all editorial decisions for the Research Topic, starting with defining its scope. This allows you to curate research around a topic that interests you, bring together different perspectives from leading researchers across different fields and shape the future of your field. 

    You will choose your team of co-editors, curate a list of potential authors, send calls for participation and oversee the peer review process, accepting or recommending rejection for each manuscript submitted.

  • As a topic editor, you're supported at every stage by our in-house team. You will be assigned a single point of contact to help you on both editorial and technical matters. Your topic is managed through our user-friendly online platform, and the peer review process is supported by our industry-first AI review assistant (AIRA).

  • If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. This provides you with valuable editorial experience, improving your ability to critically evaluate research articles and enhancing your understanding of the quality standards and requirements for scientific publishing, as well as the opportunity to discover new research in your field, and expand your professional network.

  • Yes, certificates can be issued on request. We are happy to provide a certificate for your contribution to editing a successful Research Topic.

  • Research Topics thrive on collaboration and their multi-disciplinary approach around emerging, cutting-edge themes, attract leading researchers from all over the world.

  • As a topic editor, you can set the timeline for your Research Topic, and we will work with you at your pace. Typically, Research Topics are online and open for submissions within a few weeks and remain open for participation for 6 – 12 months. Individual articles within a Research Topic are published as soon as they are ready.

    Find out more about our Research Topics

  • Our fee support program ensures that all articles that pass peer review, including those published in Research Topics, can benefit from open access – regardless of the author's field or funding situation.

    Authors and institutions with insufficient funding can apply for a discount on their publishing fees. A fee support application form is available on our website.

  • In line with our mission to promote healthy lives on a healthy planet, we do not provide printed materials. All our articles and ebooks are available under a CC-BY license, so you can share and print copies.

Participating Journals

Manuscripts can be submitted to this Research Topic via the main journal or any other participating journal.

Impact

  • 2,657Topic views
  • 1,511Article views
  • 593Article downloads
View impact