About this Research Topic
Tea drinking possesses a rich history and has gained affection from people worldwide due to its rich flavor and multiple health benefits. Lately, an array of studies have highlighted the diversity of tea's cancer-preventive and adjuvant treatments effects. With its chemical diversity linked to the various regions of origin, cultivars and most importantly, distinct forms of processing like green, black, or oolong tea, it is rich in tea polyphenols, tea saponin, carotenoids, vitamins, catechins, theabrownin, antioxidants, and minerals. Consequently, these teas have been of great interest regarding cancer prevention and adjuvant antitumor potential as well as the prevention of other major diseases
Specifically, vitamins and minerals in tea help improve immunity and boost physical wellness, assisting the immune system. Catechins play a critical role through their antioxidant, antimutagenic, and anticarcinogenic activities. Tea saponin exhibits anti-inflammatory and anticarcinogenic effects. Trihydroxyphenolic compounds like EGCG, EGC, ECG, and GC remodel stroma topology and alleviate tumor fibrosis, thus may promote tumor tissue penetration of chemotherapeutic agents.
Tea is commonly used as a food, but also as an adjuvant treatment. This research topic explores the interface between the food and medicinal use of this important species
However, the low bioavailability in vivo and the poor stability in vitro of tea's metabolites have considerably hampered their application. Thus, the development of preparations with improved bioavailability is a core aim of current research. This includes ‘intelligent nanomedicines, for example, for cancer prevention and adjuvant treatments. Key is an understanding of their mechanisms of action, It is essential to assess, whether a specific model especially an in vitro really can say s.th. about the species pharmacological effects? Polyphenols, for example, are extremely unlikely to be of major pharmacological or clinical relevance since these are known to have polyvalent effects in vitro.
In this research topic, we aim to focus on topics related to :
• Design of novel oral tea derived formulations which can be used in cancer prevention and adjuvant treatment, as well as for other disease
• Assessing potential preventive effects of tea-based formulation in the prevention of chronic conditions focusing especially on ones with a strong pro-inflammatory and immunomodulatory element
• Preparations with enhanced structural stability and retention of tea metabolites, in addition to the physical and chemical stability of tea derivative-driven intelligent nanomedicine in vivo.
• Assess site-specific delivery and programmed release of tea metabolites and other chemotherapeutics to reveal the oral/intravenous delivery's target and basic mechanism.
• Consider safety, toxicity, and biocompatibility in the development of tea-derived novel formulations used as medicines or functional foods.
We welcome contributions related to the following topics, among others:
• Comprehensive analysis of tea-derived novel formulations including composition for evaluating its pharmacological effects especially in cancer prevention and its adjuvant treatment .
• Targeting mitochondria using tea-based novel formulations focusing on preventive interventions in conditions linked to diseases with pro-inflammatory and immunomodulatory effects
• Exploration of tea-based novel formulations for adjuvant chemotherapy, free radical-mediated adjuvant tumor treatment, and other combination therapy.
• Investigations into the adjuvant effect of tea-based novel formulations in case of the use of anti-tumor chemotherapy and immunotherapy.
• Elucidating the pharmacokinetics, pharmacodynamics, toxicokinetics, and toxicodynamics of tea-based novel formulations for cancer prevention and adjuvant treatment aiming at an improved biocompatibility.
All the manuscripts submitted to the collection will need to fully comply with the Four Pillars of Best Practice in Ethnopharmacology (you can freely download the full version here).). We also expect that the MS follow the standards established in the ConPhyMP statement Front. Pharmacol. 13:953205. Please check your MS using https://ga-online.org/best-practice and you need to submit the relevant files (Table 1 and one of the options for Table 2) with your submission.
Specifically, vitamins and minerals in tea help improve immunity and boost physical wellness, assisting the immune system. Catechins play a critical role through their antioxidant, antimutagenic, and anticarcinogenic activities. Tea saponin exhibits anti-inflammatory and anticarcinogenic effects. Trihydroxyphenolic compounds like EGCG, EGC, ECG, and GC remodel stroma topology and alleviate tumor fibrosis, thus may promote tumor tissue penetration of chemotherapeutic agents.
Tea is commonly used as a food, but also as an adjuvant treatment. This research topic explores the interface between the food and medicinal use of this important species
However, the low bioavailability in vivo and the poor stability in vitro of tea's metabolites have considerably hampered their application. Thus, the development of preparations with improved bioavailability is a core aim of current research. This includes ‘intelligent nanomedicines, for example, for cancer prevention and adjuvant treatments. Key is an understanding of their mechanisms of action, It is essential to assess, whether a specific model especially an in vitro really can say s.th. about the species pharmacological effects? Polyphenols, for example, are extremely unlikely to be of major pharmacological or clinical relevance since these are known to have polyvalent effects in vitro.
In this research topic, we aim to focus on topics related to :
• Design of novel oral tea derived formulations which can be used in cancer prevention and adjuvant treatment, as well as for other disease
• Assessing potential preventive effects of tea-based formulation in the prevention of chronic conditions focusing especially on ones with a strong pro-inflammatory and immunomodulatory element
• Preparations with enhanced structural stability and retention of tea metabolites, in addition to the physical and chemical stability of tea derivative-driven intelligent nanomedicine in vivo.
• Assess site-specific delivery and programmed release of tea metabolites and other chemotherapeutics to reveal the oral/intravenous delivery's target and basic mechanism.
• Consider safety, toxicity, and biocompatibility in the development of tea-derived novel formulations used as medicines or functional foods.
We welcome contributions related to the following topics, among others:
• Comprehensive analysis of tea-derived novel formulations including composition for evaluating its pharmacological effects especially in cancer prevention and its adjuvant treatment .
• Targeting mitochondria using tea-based novel formulations focusing on preventive interventions in conditions linked to diseases with pro-inflammatory and immunomodulatory effects
• Exploration of tea-based novel formulations for adjuvant chemotherapy, free radical-mediated adjuvant tumor treatment, and other combination therapy.
• Investigations into the adjuvant effect of tea-based novel formulations in case of the use of anti-tumor chemotherapy and immunotherapy.
• Elucidating the pharmacokinetics, pharmacodynamics, toxicokinetics, and toxicodynamics of tea-based novel formulations for cancer prevention and adjuvant treatment aiming at an improved biocompatibility.
All the manuscripts submitted to the collection will need to fully comply with the Four Pillars of Best Practice in Ethnopharmacology (you can freely download the full version here).). We also expect that the MS follow the standards established in the ConPhyMP statement Front. Pharmacol. 13:953205. Please check your MS using https://ga-online.org/best-practice and you need to submit the relevant files (Table 1 and one of the options for Table 2) with your submission.
Keywords: Tea polyphenols, cancer, musculoskeletal diseases; cardiovascular diseases, diabetes, neurodegenerative diseases
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
