About this Research Topic
The field of orthopaedic rehabilitation and regeneration is witnessing significant advancements, driven by the increasing incidence of bone injuries, particularly among the aging global population. Bone injuries, including fractures and the need for bone transplantation, are prevalent clinical traumas that demand effective healing strategies. The bone regeneration process is intricate, involving a multi-stage healing process regulated by osteoblasts, mesenchymal stem cells, vascular endothelial cells, immune cells, and cytokines. Despite the progress in understanding these mechanisms, the complete regulatory pathways remain elusive. Recent studies have highlighted the potential of innovative medical technologies to enhance bone healing, emphasizing the importance of interactions between implanted devices and human tissues, as well as the controlled release of therapeutic agents. However, there is still a need for comprehensive research to fully elucidate these interactions and optimize rehabilitation processes, which could significantly improve patient outcomes and reduce economic burdens associated with orthopaedic disorders.
This research topic aims to deepen the understanding of orthopaedic-related regeneration and rehabilitation strategies by exploring the cellular and molecular mechanisms involved. The primary objective is to investigate the regulation of cellular behavior in relation to biomaterials and implanted devices, with a particular focus on biodegradable materials. By examining peri-implant bone responses, electromagnetic field therapies, and the underlying cellular and molecular mechanisms, this research seeks to bridge the gap between fundamental scientific exploration and practical clinical applications. The goal is to foster the development of novel therapies that enhance the efficacy of orthopaedic treatments.
To gather further insights in the realm of orthopaedic rehabilitation and regeneration, we welcome articles addressing, but not limited to, the following themes:
- Exploration of the roles of stem cells and/or biomaterials in bone healing, from proliferation to differentiation of stem cells.
- Examination of the interactions between biomaterials and/or osteoblasts, spanning from biocompatibility to osteogenic biological functions.
- Connection and influence mechanisms of biomaterials and/or endothelial cells in the field of angiogenesis and osteogenesis, including the activation, migration, and tube formation ability of endothelial cells.
- Investigation of the role of biomaterials in regulating immune cells in orthopaedics, with a focus on cellular and molecular mechanisms.
- Applications of innovative medical strategies and drugs within orthopaedic rehabilitation.
This research topic aims to deepen the understanding of orthopaedic-related regeneration and rehabilitation strategies by exploring the cellular and molecular mechanisms involved. The primary objective is to investigate the regulation of cellular behavior in relation to biomaterials and implanted devices, with a particular focus on biodegradable materials. By examining peri-implant bone responses, electromagnetic field therapies, and the underlying cellular and molecular mechanisms, this research seeks to bridge the gap between fundamental scientific exploration and practical clinical applications. The goal is to foster the development of novel therapies that enhance the efficacy of orthopaedic treatments.
To gather further insights in the realm of orthopaedic rehabilitation and regeneration, we welcome articles addressing, but not limited to, the following themes:
- Exploration of the roles of stem cells and/or biomaterials in bone healing, from proliferation to differentiation of stem cells.
- Examination of the interactions between biomaterials and/or osteoblasts, spanning from biocompatibility to osteogenic biological functions.
- Connection and influence mechanisms of biomaterials and/or endothelial cells in the field of angiogenesis and osteogenesis, including the activation, migration, and tube formation ability of endothelial cells.
- Investigation of the role of biomaterials in regulating immune cells in orthopaedics, with a focus on cellular and molecular mechanisms.
- Applications of innovative medical strategies and drugs within orthopaedic rehabilitation.
Keywords: Cell behavior, Regulation, Orthopaedic, Rehabilitation, Regeneration, Cell proliferation, Cell adhesion, Cell differentiation, Biomaterials, Ionic release
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
