About this Research Topic
RNA modifications have shown great promise in various applications including vaccines, gene therapy, protein engineering, functional genomics, and cellular reprogramming. RNA is enormously modified with more than 170 modifications across all living organisms. Over the past decade, researchers have shown growing interest in elucidating these modifications and their regulation by mapping RNA chemical modifications across the transcriptome using genome-scale methods. Some of these chemical modifications are N6-methyladenosine (m6A), pseudouridine (Ψ), N5-methylcytidine (m5C), N1- methyladenosine (m1A), N4-acetylcytidine (ac4C), dihydrouridine (D), and 2′-O-methyl ribose on any nucleoside (Nm). These chemical modifications are attributed to changes in the chemical properties of RNA, enhancing its stability and protecting it from nuclease degradation. Additionally, these RNA modifications impact RNA-RNA and RNA-protein interactions in various cellular processes.
The goal of this research topic is to provide a platform for the researcher to publish their ground-breaking work in RNA modification and its application in disease control. Recent advances in RNA research have demonstrated RNA's pivotal role in developing therapeutics for infectious diseases and cancer. It is still a vast research area to explore, and many researchers around the world are developing methods to study RNA chemical modifications. It is crucial to establish a platform where researchers can share their findings in this area. This collective effort is essential in advancing the field of RNA research and supporting its evolution.
• mRNA modifications in disease and regulation
• Targeting RNA modifications by small molecules
• Engineering RNA as a therapeutic agent for cancer treatment
• Interplay between translation, transcription, and RNA modifications
• mRNA modifications as a diagnostic tool for infection and disease
• mRNA splicing dependency on RNA modification in cellular processes
The goal of this research topic is to provide a platform for the researcher to publish their ground-breaking work in RNA modification and its application in disease control. Recent advances in RNA research have demonstrated RNA's pivotal role in developing therapeutics for infectious diseases and cancer. It is still a vast research area to explore, and many researchers around the world are developing methods to study RNA chemical modifications. It is crucial to establish a platform where researchers can share their findings in this area. This collective effort is essential in advancing the field of RNA research and supporting its evolution.
• mRNA modifications in disease and regulation
• Targeting RNA modifications by small molecules
• Engineering RNA as a therapeutic agent for cancer treatment
• Interplay between translation, transcription, and RNA modifications
• mRNA modifications as a diagnostic tool for infection and disease
• mRNA splicing dependency on RNA modification in cellular processes
Keywords: RNA modifications, Vaccines Gene therapy, Functional genomics, RNA-RNA interactions, RNA-protein interactions, mRNA modifications, mRNA splicing
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