The understanding of neoplastic transformation, tumorigenesis and cancer progression in humans has been significantly benefited from the use of traditional murine models. Furthermore, in recent years, novel approaches as multiomics and genome editing strategies implemented in alternative biological models have emerged as complementary tools to unveil novel mechanisms associated with cancer onset and development. Axolotl, salamander, bats and the model plant Arabidopsis thaliana have emerged as valuable models to decipher novel mechanisms for neoplastic transformation that are difficult to elucidate when traditional murine models are taken in consideration. The enrichment of biological insights derived from commonly used cancer models with novel findings obtained from unconventional ones offers a unique window to unravel the molecular circuitry that guide carcinogenesis. The suggested research topic, Expanding horizons: the use of alternative biological models in cancer research, seeks to bring together innovative research that might expand the traditional framework linked with cancer research, also exploring how recent findings in alternative biological models can pave the way for a better and more complete view of cancer biology.
The central aim of the present Research Topic is to complement the understanding of the carcinogenic process by exploring and depicting the molecular machinery associated with cancer onset and progression in alternative biological models. Specifically, contributions to this collection seek to explore knowledge transferring between unconventional and traditional biological models to expand the understanding of how evolutionarily conserved molecular and genetic mechanisms can provide insights into carcinogenesis and tumor progression. Papers are also encouraged to explore recent advances in gene editing, transcriptomics, proteomics, interactomics, and comparative genomics applied to these models to show how the described advances can be essential to elucidate the molecular basis of cancer. With this collection, we want to foster and motivate a multidisciplinary discussion that contributes with the identification and characterization of new molecular elements and even novel therapeutic targets for cancer diagnosis and treatment.
The central aim of the present research topic is to complement the understanding of the carcinogenic process by exploring and depicting the molecular machinery associated with cancer onset and progression in alternative biological models. We invite authors to submit original research, reviews, metanalyses, and opinion articles addressing (but not limited) the following topics:
•The implementation of comparative genomics strategies to characterize the molecular machinery associated with cancer onset and progression.
•The application of genome editing strategies to generate alternative models for cancer research.
•The development of novel strategies to translate findings derived from unconventional cancer models to humans.
•The implementation of alternative biological models to elucidate the molecular and genetic circuitry underlying carcinogenesis.
•The disclosure or recent advances in gene editing, transcriptomics, proteomics and interactomics techniques applied to unconventional cancer models in the context of cancer research.
We are particularly interested in manuscripts that offer an interdisciplinary perspective to build novel knowledge through the implementation of unconventional models for cancer research. We encourage the submission of studies that promote innovative research that might expand the traditional framework linked with cancer research, exploring how recent findings in alternative biological models can pave the way for a better and more comprehensive view of cancer
Keywords:
Cancer-Hallmarks, cancer biology, cancer biological models, comparative genomics, neoplastic transformation and carcinogenesis
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
The understanding of neoplastic transformation, tumorigenesis and cancer progression in humans has been significantly benefited from the use of traditional murine models. Furthermore, in recent years, novel approaches as multiomics and genome editing strategies implemented in alternative biological models have emerged as complementary tools to unveil novel mechanisms associated with cancer onset and development. Axolotl, salamander, bats and the model plant Arabidopsis thaliana have emerged as valuable models to decipher novel mechanisms for neoplastic transformation that are difficult to elucidate when traditional murine models are taken in consideration. The enrichment of biological insights derived from commonly used cancer models with novel findings obtained from unconventional ones offers a unique window to unravel the molecular circuitry that guide carcinogenesis. The suggested research topic, Expanding horizons: the use of alternative biological models in cancer research, seeks to bring together innovative research that might expand the traditional framework linked with cancer research, also exploring how recent findings in alternative biological models can pave the way for a better and more complete view of cancer biology.
The central aim of the present Research Topic is to complement the understanding of the carcinogenic process by exploring and depicting the molecular machinery associated with cancer onset and progression in alternative biological models. Specifically, contributions to this collection seek to explore knowledge transferring between unconventional and traditional biological models to expand the understanding of how evolutionarily conserved molecular and genetic mechanisms can provide insights into carcinogenesis and tumor progression. Papers are also encouraged to explore recent advances in gene editing, transcriptomics, proteomics, interactomics, and comparative genomics applied to these models to show how the described advances can be essential to elucidate the molecular basis of cancer. With this collection, we want to foster and motivate a multidisciplinary discussion that contributes with the identification and characterization of new molecular elements and even novel therapeutic targets for cancer diagnosis and treatment.
The central aim of the present research topic is to complement the understanding of the carcinogenic process by exploring and depicting the molecular machinery associated with cancer onset and progression in alternative biological models. We invite authors to submit original research, reviews, metanalyses, and opinion articles addressing (but not limited) the following topics:
•The implementation of comparative genomics strategies to characterize the molecular machinery associated with cancer onset and progression.
•The application of genome editing strategies to generate alternative models for cancer research.
•The development of novel strategies to translate findings derived from unconventional cancer models to humans.
•The implementation of alternative biological models to elucidate the molecular and genetic circuitry underlying carcinogenesis.
•The disclosure or recent advances in gene editing, transcriptomics, proteomics and interactomics techniques applied to unconventional cancer models in the context of cancer research.
We are particularly interested in manuscripts that offer an interdisciplinary perspective to build novel knowledge through the implementation of unconventional models for cancer research. We encourage the submission of studies that promote innovative research that might expand the traditional framework linked with cancer research, exploring how recent findings in alternative biological models can pave the way for a better and more comprehensive view of cancer
Keywords:
Cancer-Hallmarks, cancer biology, cancer biological models, comparative genomics, neoplastic transformation and carcinogenesis
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.