Posterior Capsule Opacification

Despite improvements in cataract surgery, posterior capsule opacification (PCO) is still a clinically significant cause of secondary vision loss. Even minor PCO that does not cause substantial obstruction of the central visual axis can reduce the quality of vision by increasing glare. Any reduction in the rate or severity of PCO formation would stand to improve the visual outcome following cataract surgery in a large number of patients. Therefore, understanding the factors leading to PCO development and formulating novel ways to prevent PCO is of critical importance to the global population.

This Research Topic features research and review articles by leading scientists on posterior capsule opacification (PCO). Topics to be covered include:
- Mechanism of action associated with the development of either fibrotic PCO or regenerative PCO (Elschnig’s Pearls and Soemmering's ring)
- Interaction of lens epithelial cells with the capsule
- Biomechanical influence on PCO
- Basic science or clinical approaches to slow or prevent PCO
- Clinical determinants to PCO formation: effect of age or inflammation
- Animal models of PCO
- Correlations between physician- and veterinary-based ophthalmology

Keywords: Posterior Capsule Opacification, PCO, Fibrotic PCO, Regenerative PCO

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.