About this Research Topic
Epicardial adipose tissue (EAT) represents a distinct accumulation of fat enveloping the heart, situated between the myocardium and the visceral pericardium. It exerts a range of effects across multiple physiological strata, including glucose and lipid metabolism, heat production, and secretion, all of which affect the structure of the heart. Recently, EAT has garnered attention for its potential role in the diagnosis and therapeutical management of heart failure. For instance, elevated EAT levels has been associated with the incidence of heart failure with preserved ejection fraction (HFpEF), abundant EAT in HFpEF patients indicated a poorer prognosis. Additionally, EAT has been correlated with structural and functional myocardial abnormalities in HFpEF, such as myocardial hypertrophy, diastolic dysfunction and increased filling pressures. This may be attributed to the role that EAT as a sensor mediating the effects of systemic inflammation on the myocardium. However, many questions regarding the role of EAT on heart failure (HF) remain unanswered. Further research exploring the mechanisms, diagnosis role and therapeutical potential of EAT in HF is required. We hope to gain more instructive scientific findings to promote HF therapy and guide future clinical applications.
In this research topic focusing on Epicardial adipose tissue (EAT), we would like to create a forum for research touching upon the cellular and physiological mechanisms linking EAT and Heart failure (HF). We also hope to shed light on the potential diagnostic and prognostic application of EAT on HF identification. In addition, identifying therapeutic strategies expressly focused on regulating EAT accumulation to improve outcomes for HF patients is a focused scientific research question we’d like to explore in this research topic.
Authors are invited to submit Original Research, Review, Mini Review, Methodology Papers and Case Reports on the sub-topics, but not limited to:
- The biological mechanism of EAT in mediating development of HF
- The application of EAT in HF diagnosis and prognosis
- The strategies of regulating EAT production and accumulation
- Metabolic changes of EAT in HF
- Advanced imaging techniques for EAT identifying, phenotyping and structural measurements
In this research topic focusing on Epicardial adipose tissue (EAT), we would like to create a forum for research touching upon the cellular and physiological mechanisms linking EAT and Heart failure (HF). We also hope to shed light on the potential diagnostic and prognostic application of EAT on HF identification. In addition, identifying therapeutic strategies expressly focused on regulating EAT accumulation to improve outcomes for HF patients is a focused scientific research question we’d like to explore in this research topic.
Authors are invited to submit Original Research, Review, Mini Review, Methodology Papers and Case Reports on the sub-topics, but not limited to:
- The biological mechanism of EAT in mediating development of HF
- The application of EAT in HF diagnosis and prognosis
- The strategies of regulating EAT production and accumulation
- Metabolic changes of EAT in HF
- Advanced imaging techniques for EAT identifying, phenotyping and structural measurements
Keywords: Epicardial Adipose Tissue, Heart Failure, Mechanism, Diagnosis, Metabolism
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
