About this Research Topic
RNA molecules were traditionally viewed as passive carriers of genetic information, but it is now clear that they are highly dynamic entities subject to a multitude of chemical modifications that significantly impact their structure, function, and regulatory roles within the cell. High-throughput sequencing techniques, advanced mass spectrometry, and innovative biochemical assays have empowered scientists to map modification sites across the transcriptome and investigate their functional consequences with unprecedented precision. Researchers have made remarkable progress in unravelling the mechanisms underlying the addition, removal, and recognition of these modifications and all these discoveries of RNA post-transcriptional modifications (PTMs) have transformed our understanding of the complexity and versatility of RNA molecules. The significance of RNA PTMs extends to virtually all aspects of biology. They are now recognized as key regulators of gene expression, influencing the fate and function of RNA molecules across a wide range of biological processes, including development, differentiation, immune response, and disease pathogenesis. Dysregulation of these modifications has been linked to various diseases, including cancer, neurological disorders, and metabolic diseases, making them attractive targets for therapeutic intervention.
The objective of this research domain is to elucidate the existing knowledge concerning the landscape of PTMs on RNAs and their pivotal roles in the genesis and progression of various diseases. Our pursuit involves the exploration of cutting-edge analytical methodologies to comprehensively unveil PTM mutations on RNAs. Furthermore, we endeavor to employ innovative approaches aimed at elucidating the intricate mechanisms and consequential significance of PTM mutations across a spectrum of diseases. Contributions in the form of systematic reviews and original research are eagerly anticipated and welcomed within this thematic collection.
This issue aims to provide a platform for researchers to share their latest findings, insights, and innovations in the realm of RNA post-transcriptional modifications. We invite contributions that span a wide range of topics within this field, including but not limited to:
• Emerging technologies and tools for the detection and quantification of RNA modifications.
• Mechanisms of RNA modification deposition and removal.
• Functional roles of RNA modifications in translation and cellular processes.
• The role of RNA modifications in disease pathogenesis and therapeutic strategies.
• Cross-talk between RNA modifications and other epigenetic marks.
The objective of this research domain is to elucidate the existing knowledge concerning the landscape of PTMs on RNAs and their pivotal roles in the genesis and progression of various diseases. Our pursuit involves the exploration of cutting-edge analytical methodologies to comprehensively unveil PTM mutations on RNAs. Furthermore, we endeavor to employ innovative approaches aimed at elucidating the intricate mechanisms and consequential significance of PTM mutations across a spectrum of diseases. Contributions in the form of systematic reviews and original research are eagerly anticipated and welcomed within this thematic collection.
This issue aims to provide a platform for researchers to share their latest findings, insights, and innovations in the realm of RNA post-transcriptional modifications. We invite contributions that span a wide range of topics within this field, including but not limited to:
• Emerging technologies and tools for the detection and quantification of RNA modifications.
• Mechanisms of RNA modification deposition and removal.
• Functional roles of RNA modifications in translation and cellular processes.
• The role of RNA modifications in disease pathogenesis and therapeutic strategies.
• Cross-talk between RNA modifications and other epigenetic marks.
Keywords: RNA modification, epistructurome, post-transcriptional regulation, protein translation, RNA folding, biological function, PTM analysis technics
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