About this Research Topic
Insulin resistance is an important metabolic abnormality that is not only associated with diabetes and cardiovascular disease, but recent studies have also found that it builds a tight bridge between tumors and inflammation. Insulin is a key hormone whose primary role is to promote the uptake and utilization of glucose by cells in the body in order to maintain a stable blood glucose level. However, in a state of insulin resistance, cells become less responsive to insulin, resulting in more insulin required to achieve the same level of glucose uptake. This metabolic abnormality is usually accompanied by hyperinsulinemia.
High insulin levels may affect the cancer development. First, insulin is a growth factor that stimulates the growth and division of cells, including cancer cells. Therefore, high insulin levels may directly contribute to the abnormal proliferation of cancer cells, thus encouraging tumor formation and development. In addition, insulin resistance is closely linked to chronic inflammatory processes. Chronic inflammation is an important factor in the development of cancer by altering the cellular environment and contributing to the malignant transformation of cells. High insulin levels are thought to potentially play a role in the inflammatory process, leading to the release of inflammatory cytokines and an increased inflammatory response.
Thus, insulin resistance appears to bridge the gap between tumors and inflammation. This bridge connects metabolic abnormalities and cancer development, providing new perspectives to delve into tumor pathogenesis, explore new therapeutic strategies, and better manage patients with insulin resistance. Therefore, the aim of this Research Topic is to gain a deeper understanding of tumor glucose metabolic processes, explore research strategies for insulin resistance, and propose future directions in related fields.
We welcome submissions of Original Research, Reviews, Mini-reviews, Methodologies, Perspectives and Opinion articles surrounding, but not limited to, the following topics.
• Molecular mechanism studies: In-depth investigation of how insulin resistance affects intracellular signaling pathways, especially those involved in cell growth and cancer development, in order to unravel their molecular mechanisms.
• Mechanisms of cancer development: To study the effects of insulin resistance on cancer cells, including mechanisms of cell proliferation, survival, metastasis and drug resistance, in order to develop new therapeutic strategies.
• Inflammation and immune response: To explore how insulin resistance triggers or exacerbates inflammatory responses and how inflammation affects tumor development, in order to find ways to intervene in the inflammation-tumor association.
• Pharmacological interventions: to develop and evaluate drugs targeting insulin resistance and their potential efficacy in cancer development, and to find new therapeutic approaches.
• Clinical studies: To study the relationship between insulin resistance and cancer in clinical patients, both diabetic and non-diabetic, and how to better manage these patients.
• Molecular markers and targeted therapies: Finding molecular markers associated with insulin resistance and whether they can be used in the early diagnosis and treatment of cancer, as well as developing targeted therapeutic strategies.
High insulin levels may affect the cancer development. First, insulin is a growth factor that stimulates the growth and division of cells, including cancer cells. Therefore, high insulin levels may directly contribute to the abnormal proliferation of cancer cells, thus encouraging tumor formation and development. In addition, insulin resistance is closely linked to chronic inflammatory processes. Chronic inflammation is an important factor in the development of cancer by altering the cellular environment and contributing to the malignant transformation of cells. High insulin levels are thought to potentially play a role in the inflammatory process, leading to the release of inflammatory cytokines and an increased inflammatory response.
Thus, insulin resistance appears to bridge the gap between tumors and inflammation. This bridge connects metabolic abnormalities and cancer development, providing new perspectives to delve into tumor pathogenesis, explore new therapeutic strategies, and better manage patients with insulin resistance. Therefore, the aim of this Research Topic is to gain a deeper understanding of tumor glucose metabolic processes, explore research strategies for insulin resistance, and propose future directions in related fields.
We welcome submissions of Original Research, Reviews, Mini-reviews, Methodologies, Perspectives and Opinion articles surrounding, but not limited to, the following topics.
• Molecular mechanism studies: In-depth investigation of how insulin resistance affects intracellular signaling pathways, especially those involved in cell growth and cancer development, in order to unravel their molecular mechanisms.
• Mechanisms of cancer development: To study the effects of insulin resistance on cancer cells, including mechanisms of cell proliferation, survival, metastasis and drug resistance, in order to develop new therapeutic strategies.
• Inflammation and immune response: To explore how insulin resistance triggers or exacerbates inflammatory responses and how inflammation affects tumor development, in order to find ways to intervene in the inflammation-tumor association.
• Pharmacological interventions: to develop and evaluate drugs targeting insulin resistance and their potential efficacy in cancer development, and to find new therapeutic approaches.
• Clinical studies: To study the relationship between insulin resistance and cancer in clinical patients, both diabetic and non-diabetic, and how to better manage these patients.
• Molecular markers and targeted therapies: Finding molecular markers associated with insulin resistance and whether they can be used in the early diagnosis and treatment of cancer, as well as developing targeted therapeutic strategies.
Keywords: Insulin resistance, Cancer, Inflammation, Glucose metabolism, Molecular markers
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
