About this Research Topic
Despite receiving very little attention in comparison to invertebrate models or rodents, the basic gerontological features of small laboratory fishes provide interesting data for further investigation. In particular, guppies have proved to be an important model for evolutionary analyses of aging, killifish are short-lived and may be exploitable for life span alteration studies, and zebrafish come with a formidable asset of associated biological tools from their widespread use as a model of vertebrate development. Along with this, investigation of basic processes implicated in aging, such as insulin signaling, oxidative stress, and comparative studies of species (or strains) with divergent longevities can be done, allowing these organisms to join the group of well-established aging models including yeast, Caenorhabditis elegans, and Drosophila.
The goal of this collection is to collect valuable research using these models, with particular attention to the molecular and genetic aspects of aging, both in physiological and pathological contexts. With the use of genome editing techniques, models as zebrafish, or N. furzeri and other small laboratory fishes, should be ideal to explore genes and pathways that control aging in vertebrates, including epigenetics, metabolism, and behavior, as well as studying the importance of the microbiome in aging. In the future, they could serve as a basis to perform high-throughput genetic and pharmacological screens for genes and substances that alter aging, as well as aging-associated diseases.
The scope of the current Research Topic is to cover the recent research using these models. We welcome original research articles, systematic review, meta-analysis, clinical case studies, and review articles within the scope of the research topic. Topic of interests includes, but are not limited to the following:
•Use of genome editing tools to study gene regulatory networks in the context of aging
•Analysis of omics data (both bulk and single-cell ones)
•Pharmacological screens
•Alteration of metabolism during aging
•Effect of nutrition, and of the alteration of the microbiome, on aging
•Brain aging and neurodegenerative diseases
•Investigating the role of the killifish as model for aging-related diseases
The goal of this collection is to collect valuable research using these models, with particular attention to the molecular and genetic aspects of aging, both in physiological and pathological contexts. With the use of genome editing techniques, models as zebrafish, or N. furzeri and other small laboratory fishes, should be ideal to explore genes and pathways that control aging in vertebrates, including epigenetics, metabolism, and behavior, as well as studying the importance of the microbiome in aging. In the future, they could serve as a basis to perform high-throughput genetic and pharmacological screens for genes and substances that alter aging, as well as aging-associated diseases.
The scope of the current Research Topic is to cover the recent research using these models. We welcome original research articles, systematic review, meta-analysis, clinical case studies, and review articles within the scope of the research topic. Topic of interests includes, but are not limited to the following:
•Use of genome editing tools to study gene regulatory networks in the context of aging
•Analysis of omics data (both bulk and single-cell ones)
•Pharmacological screens
•Alteration of metabolism during aging
•Effect of nutrition, and of the alteration of the microbiome, on aging
•Brain aging and neurodegenerative diseases
•Investigating the role of the killifish as model for aging-related diseases
Keywords: Aging, Nothobranchius furzeri, Omics, Neuroscience, Development
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
