About this Research Topic
Angiogenesis, the formation of new blood vessels from existing ones, is a crucial process in development, wound healing, and reproduction. However, its dysregulation contributes to diseases like cancer, arthritis, and psoriasis. Angiogenesis is modulated by a balance of pro- and anti-angiogenic factors, including growth factors, cytokines, hypoxia, and inflammation. Pharmacological modulation of angiogenesis, using drugs to promote or inhibit it, holds promise for treating various diseases. Angiogenesis inhibitors can combat cancer by preventing tumor growth and spread, while angiogenesis promoters can aid wound healing and address insufficient blood flow. Despite challenges in targeting angiogenesis without affecting other processes and the complexity of the process, pharmacological modulation of angiogenesis remains a promising field with potential to revolutionize disease treatment.
The pharmacological modulation of angiogenesis has made significant progress in recent years. FDA-approved angiogenesis inhibitors have been developed for cancer treatment. Novel angiogenesis promoters with promising preclinical results have also been developed. Additionally, new delivery methods for angiogenesis drugs, such as nanoparticles and liposomes, have been developed. Combination therapies have also been shown to be more effective than either treatment alone. However, despite the progress, challenges still remain. More effective and specific angiogenesis inhibitors and promoters are needed. Better ways to deliver angiogenesis drugs to target tissues are also needed. Researchers are working to address these challenges and develop even more effective angiogenesis drugs in the future.
Some of the specific research fields and themes that are being explored include:
This Research Topic welcomes original research articles and review articles focusing on, but not limited to, the following themes:
• Angiogenesis inhibitors: These drugs are designed to block the formation of new blood vessels, which can be used to treat cancer and other diseases that are characterized by excessive angiogenesis.
• Angiogenesis promoters: These drugs are designed to promote the formation of new blood vessels, which can be used to treat conditions such as peripheral artery disease and wound healing.
• Delivery of angiogenesis drugs: Developing new and improved methods for delivering angiogenesis drugs to target tissues is essential for maximizing their effectiveness and minimizing side effects.
• Combination therapies: Combining angiogenesis drugs with other therapies, such as chemotherapy or radiation therapy, can often be more effective than either treatment alone.
The pharmacological modulation of angiogenesis has made significant progress in recent years. FDA-approved angiogenesis inhibitors have been developed for cancer treatment. Novel angiogenesis promoters with promising preclinical results have also been developed. Additionally, new delivery methods for angiogenesis drugs, such as nanoparticles and liposomes, have been developed. Combination therapies have also been shown to be more effective than either treatment alone. However, despite the progress, challenges still remain. More effective and specific angiogenesis inhibitors and promoters are needed. Better ways to deliver angiogenesis drugs to target tissues are also needed. Researchers are working to address these challenges and develop even more effective angiogenesis drugs in the future.
Some of the specific research fields and themes that are being explored include:
This Research Topic welcomes original research articles and review articles focusing on, but not limited to, the following themes:
• Angiogenesis inhibitors: These drugs are designed to block the formation of new blood vessels, which can be used to treat cancer and other diseases that are characterized by excessive angiogenesis.
• Angiogenesis promoters: These drugs are designed to promote the formation of new blood vessels, which can be used to treat conditions such as peripheral artery disease and wound healing.
• Delivery of angiogenesis drugs: Developing new and improved methods for delivering angiogenesis drugs to target tissues is essential for maximizing their effectiveness and minimizing side effects.
• Combination therapies: Combining angiogenesis drugs with other therapies, such as chemotherapy or radiation therapy, can often be more effective than either treatment alone.
Keywords: Angiogenesis, antiangiogenic therapy, proangiogenic drugs, drug discovery, drug delivery
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