About this Research Topic

Background

Coronary artery disease (CAD) is the leading cause of death worldwide, with acute myocardial infarction (MI) representing the clinical condition associated with the greatest morbidity and mortality, accounting for up to 30% of in-hospital deaths. Advances in acute cardiovascular care, including prompt reperfusion with percutaneous coronary intervention (PCI) and more effective medical therapy, have significantly improved the prognosis of MI patients in recent years. However, this increased survival has revealed a previously unrecognized short- and long-term risk of recurrent cardiovascular events despite optimal medical therapy. Nearly one-fifth of MI patients experience rehospitalization within one year, and 10% suffer from recurrent MI. Current guidelines from the American Heart Association and the European Society of Cardiology highlight the lack of useful biomarkers to predict in-hospital complications and short/long-term prognosis of MI patients, recommending only the measurement of troponin and brain natriuretic peptide (BNP) serum levels, with the latter associated with a low level of evidence. Although several studies, particularly those conducted in the 90s before the routine use of dual antiplatelet therapy, have described the pivotal and prognostic role of coronary thrombosis and hypercoagulable state in MI, conclusive data on the real usefulness and additional value of biomarkers in the management of MI patients are still lacking.

This research topic aims to provide new evidence and summarize current evidence on the potential prognostic role of inflammatory and thrombotic biomarkers in patients with acute coronary syndrome. The main objectives include identifying specific biomarkers that can improve risk stratification, predicting adverse events, and enhancing the prognosis of MI patients. By addressing these questions, the research seeks to fill the existing gaps in knowledge and offer a more comprehensive understanding of the role of these biomarkers in clinical practice.

To gather further insights into the prognostic role of inflammatory and thrombotic biomarkers in MI, we welcome articles addressing, but not limited to, the following themes:

- Identification and validation of novel inflammatory and thrombotic biomarkers in MI.
- Comparative studies on the prognostic value of existing biomarkers.
- Mechanistic studies elucidating the role of inflammation and thrombosis in MI pathophysiology.
- Clinical trials assessing the impact of biomarker-guided therapy on patient outcomes.
- Meta-analyses and systematic reviews summarizing current evidence on biomarkers in MI.
- Development of risk stratification models incorporating inflammatory and thrombotic biomarkers.
- Evaluation of the cost-effectiveness of biomarker-based strategies in MI management.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Editorial
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Editorial
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Policy and Practice Reviews
• Review
• Study Protocol
• Systematic Review

Keywords: biomarkers, myocardial infarction, thrombosis, thrombotic biomarkers, coronary artery disease

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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