Synergistic Approaches to Managing Gram-negative Bacterial Resistance

The rapidly increasing prevalence of multi-resistant Gram-negative bacteria poses a severe threat to public health globally. An in-depth understanding of disease development by these bacteria, alongside their genomic and phenotypic resistance traits, and mechanisms of spread, is crucial to counter this risk effectively. Recent studies have elucidated some of the critical pathways in bacterial resistance development and disease pathogenesis, yet a comprehensive integration of these findings into therapeutic and containment strategies remains partial. The need to incorporate the attributes of specific bacterial species and their interactions with host organisms is vital for a holistic approach in tackling antimicrobial resistance.

This research topic aims to integrate current knowledge on bacterial resistance, virulence, and host cell interactions into a unified framework. The goal is to leverage the synergy from these integrative studies to push forward new insights in disease management, focusing notably on treatment and prevention strategies. By bridging gaps between direct pathogen research and host-associated factors, including immune system responses and microbiome interactions, this initiative anticipates breakthroughs in understanding and combatting bacterial infections.

To comprehensively explore this pressing issue, we invite contributions that address various facets of Gram-negative bacterial resistance and infection pathogenesis. We encourage submissions not limited to, but including:
- Genomic studies on antimicrobial resistance
- Research on host-pathogen interactions, particularly involving the immune system and microbiome
- Epidemiological analyses detailing the spread of resistance traits

Contributions can range from Original Research and Brief Research Report to Mini-reviews and Reviews, all aiming to contribute to a robust scientific discourse on combating Gram-negative bacterial resistance.