About this Research Topic
Neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's pose significant challenges to both patients and healthcare systems worldwide. While considerable progress has been made in understanding the underlying molecular mechanisms, the translation of this knowledge into effective therapies remains limited. This Research Topic aims to provide a comprehensive overview of the considerations involved in translating therapies for neurodegenerative diseases. By exploring model systems, designing therapeutics, testing modalities, and enabling clinical translation, we seek to bridge the gap between basic research and clinical applications, ultimately improving patient outcomes.
The main goal of this Research Topic is to address the obstacles hindering the successful translation of potential therapies for neurodegenerative diseases. By bringing together experts from diverse fields, we aim to identify key areas that require attention and propose innovative strategies to overcome these challenges. Our focus will be on elucidating the factors that impede the progression of promising therapeutic candidates from bench to bedside. By doing so, we hope to provide a roadmap for researchers, clinicians, and pharmaceutical companies to facilitate the development and implementation of effective treatments for neurodegenerative diseases.
This Research Topic invites contributions addressing various aspects of translating therapies for neurodegenerative diseases. Specific themes of interest include, but are not limited to:
- The development and utilization of model systems, including in vitro and animal models
- Novel therapeutic approaches, including small molecules, biologics, gene therapies, and cell-based therapies
- Innovative testing modalities, such as biomarkers, imaging techniques, and non-invasive assessments
- Overcoming regulatory and ethical challenges in preclinical and clinical translation
- Strategies for optimizing clinical trial design and patient selection
- Translational success stories and lessons learned from both successful and unsuccessful therapies
We encourage the submission of original research articles, reviews, perspectives, and opinion papers from researchers, clinicians, and industry professionals working in the field of neurodegenerative diseases and translational medicine. By fostering interdisciplinary collaboration, this Research Topic aims to accelerate the development of effective therapies and ultimately improve the lives of patients affected by neurodegenerative disorders.
The main goal of this Research Topic is to address the obstacles hindering the successful translation of potential therapies for neurodegenerative diseases. By bringing together experts from diverse fields, we aim to identify key areas that require attention and propose innovative strategies to overcome these challenges. Our focus will be on elucidating the factors that impede the progression of promising therapeutic candidates from bench to bedside. By doing so, we hope to provide a roadmap for researchers, clinicians, and pharmaceutical companies to facilitate the development and implementation of effective treatments for neurodegenerative diseases.
This Research Topic invites contributions addressing various aspects of translating therapies for neurodegenerative diseases. Specific themes of interest include, but are not limited to:
- The development and utilization of model systems, including in vitro and animal models
- Novel therapeutic approaches, including small molecules, biologics, gene therapies, and cell-based therapies
- Innovative testing modalities, such as biomarkers, imaging techniques, and non-invasive assessments
- Overcoming regulatory and ethical challenges in preclinical and clinical translation
- Strategies for optimizing clinical trial design and patient selection
- Translational success stories and lessons learned from both successful and unsuccessful therapies
We encourage the submission of original research articles, reviews, perspectives, and opinion papers from researchers, clinicians, and industry professionals working in the field of neurodegenerative diseases and translational medicine. By fostering interdisciplinary collaboration, this Research Topic aims to accelerate the development of effective therapies and ultimately improve the lives of patients affected by neurodegenerative disorders.
Keywords: neurodegenerative diseases, translating therapies, model systems, therapeutics, testing modalities, clinical translation
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
