The oral and gut barriers are critical interfaces for the interaction between the microbiota and host immune cells. These interactions may maintain a tolerogenic environment but also be involved in the pathogenesis of infectious and inflammatory diseases. Increasing evidence suggests that microbiota-derived molecule translocation and/or immune cell activation and migration from barrier tissues to distant sites may contribute to systemic disease development. Thus, the exploration of immune responses at barrier tissues and crosstalk between the oral and gut mucosa is crucial for the understanding of the immunopathogenesis of a myriad of local and systemic diseases and the design of therapeutic strategies.
This Special Issue aims to highlight and discuss the latest findings regarding microbiota-host interactions and immune responses in oral and gut mucosal tissues. Particularly, the microbiota- and host-derived factors involved in the crosstalk between oral and gut barriers. Furthermore, this Research Topic will emphasize the impact of oral and gut barrier tissues on the development and progression of systemic diseases and spotlight novel translational approaches for the design of therapeutics and vaccines targeting mucosal sites.
We seek Original Research, Review, Mini-Review, Hypothesis and Theory, Perspective, Clinical Trial, Case Report and Opinion articles that cover, but are not limited to, the following topics:
• Immune responses at oral or gut barriers in vitro and in vivo
• Crosstalk between oral or gut microbiota and immune cells
• The role of the commensal oral and gut microbiota on systemic diseases
• Modulation of gut microbiota by oral pathobionts
• Role of oral or gut microbiota and its metabolites on the modulation of local and systemic immune responses
• Effects of oral or gut dysbiosis on systemic disease
• Interaction of genetic factors in the oral or gut axis
• Antigen-presentation of microbial-derived molecules in molecular mimicry at the oral or gut barrier
• The role of host- and microbial-derived membrane vesicles on oral-gut cross-talk and systemic disease.
• Therapeutic approaches directed to oral or gut microbiota and microbial-derived molecules.
• Oral vaccine approaches against pathogens using i.e. bacterial-derived membrane vesicles or viral vectors.
With this Research Topic, we hope to encourage scientists, clinicians, and bioengineers to share their knowledge, groundbreaking results, and visionary perspectives to contribute to the elucidation of local and systemic immune interactions at barrier tissues and enrich this multidisciplinary discourse.
Keywords:
Barrier tissues, microbiota, pathobionts, mucosal immunity, membrane vesicles, mucosal vaccines, systemic disease, oral-gut axis, mucosal barriers
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
The oral and gut barriers are critical interfaces for the interaction between the microbiota and host immune cells. These interactions may maintain a tolerogenic environment but also be involved in the pathogenesis of infectious and inflammatory diseases. Increasing evidence suggests that microbiota-derived molecule translocation and/or immune cell activation and migration from barrier tissues to distant sites may contribute to systemic disease development. Thus, the exploration of immune responses at barrier tissues and crosstalk between the oral and gut mucosa is crucial for the understanding of the immunopathogenesis of a myriad of local and systemic diseases and the design of therapeutic strategies.
This Special Issue aims to highlight and discuss the latest findings regarding microbiota-host interactions and immune responses in oral and gut mucosal tissues. Particularly, the microbiota- and host-derived factors involved in the crosstalk between oral and gut barriers. Furthermore, this Research Topic will emphasize the impact of oral and gut barrier tissues on the development and progression of systemic diseases and spotlight novel translational approaches for the design of therapeutics and vaccines targeting mucosal sites.
We seek Original Research, Review, Mini-Review, Hypothesis and Theory, Perspective, Clinical Trial, Case Report and Opinion articles that cover, but are not limited to, the following topics:
• Immune responses at oral or gut barriers in vitro and in vivo
• Crosstalk between oral or gut microbiota and immune cells
• The role of the commensal oral and gut microbiota on systemic diseases
• Modulation of gut microbiota by oral pathobionts
• Role of oral or gut microbiota and its metabolites on the modulation of local and systemic immune responses
• Effects of oral or gut dysbiosis on systemic disease
• Interaction of genetic factors in the oral or gut axis
• Antigen-presentation of microbial-derived molecules in molecular mimicry at the oral or gut barrier
• The role of host- and microbial-derived membrane vesicles on oral-gut cross-talk and systemic disease.
• Therapeutic approaches directed to oral or gut microbiota and microbial-derived molecules.
• Oral vaccine approaches against pathogens using i.e. bacterial-derived membrane vesicles or viral vectors.
With this Research Topic, we hope to encourage scientists, clinicians, and bioengineers to share their knowledge, groundbreaking results, and visionary perspectives to contribute to the elucidation of local and systemic immune interactions at barrier tissues and enrich this multidisciplinary discourse.
Keywords:
Barrier tissues, microbiota, pathobionts, mucosal immunity, membrane vesicles, mucosal vaccines, systemic disease, oral-gut axis, mucosal barriers
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.