Adenosine, a fundamental purine nucleoside, functions as a crucial endogenous signaling molecule involved in maintaining cardiovascular and smooth muscle homeostasis. It exerts diverse physiological effects through adenosine receptors located in various cardiovascular tissues and cell types. Adenosine acts as a potent vasodilator, influencing vascular tone regulation and blood flow distribution. It also modulates cardiac contractility, neuronal signaling, and immune responses, thereby impacting cardiovascular health and disease. Dysregulation of adenosine metabolism has emerged as a pivotal factor in the pathogenesis of several cardiovascular disorders, including ischemic heart disease, heart failure, arrhythmias, and vascular remodeling.
Key enzymes such as adenosine kinase, ectonucleotidases, adenosine deaminase, nucleoside phosphorylases, and adenosine transporters regulate the production, conversion, and clearance of adenosine. Alterations in these enzymes can disrupt adenosine homeostasis, resulting in abnormal adenosine levels and subsequent cardiovascular dysfunction.
Understanding the molecular mechanisms underlying adenosine metabolism, as well as its intricate interaction with adenosine receptors, is crucial for unraveling the intricate interplay between adenosine and cardiovascular health and disease. Recent advances in this field have identified novel enzymatic pathways, regulatory mechanisms, and genetic variants influencing adenosine metabolism. These discoveries have paved the way for investigating the therapeutic potential of targeting adenosine metabolism for the prevention and treatment of cardiovascular disorders.
This Research Topic seeks to explore the multifaceted roles of adenosine metabolism in cardiovascular and smooth muscle health and disease, aiming to shed light on the underlying mechanisms and identify novel therapeutic strategies. By bringing together research in molecular biology, physiology, pharmacology, and clinical studies, this Research Topic aims to unravel the complexities of adenosine metabolism and its potential as a therapeutic target in various cardiovascular conditions welcoming the submission of original research as well as review articles.
Keywords:
adenosine metabolism, adenosine, adenosine deaminase, nucleoside phosphorylases, molecular mechanisms
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Adenosine, a fundamental purine nucleoside, functions as a crucial endogenous signaling molecule involved in maintaining cardiovascular and smooth muscle homeostasis. It exerts diverse physiological effects through adenosine receptors located in various cardiovascular tissues and cell types. Adenosine acts as a potent vasodilator, influencing vascular tone regulation and blood flow distribution. It also modulates cardiac contractility, neuronal signaling, and immune responses, thereby impacting cardiovascular health and disease. Dysregulation of adenosine metabolism has emerged as a pivotal factor in the pathogenesis of several cardiovascular disorders, including ischemic heart disease, heart failure, arrhythmias, and vascular remodeling.
Key enzymes such as adenosine kinase, ectonucleotidases, adenosine deaminase, nucleoside phosphorylases, and adenosine transporters regulate the production, conversion, and clearance of adenosine. Alterations in these enzymes can disrupt adenosine homeostasis, resulting in abnormal adenosine levels and subsequent cardiovascular dysfunction.
Understanding the molecular mechanisms underlying adenosine metabolism, as well as its intricate interaction with adenosine receptors, is crucial for unraveling the intricate interplay between adenosine and cardiovascular health and disease. Recent advances in this field have identified novel enzymatic pathways, regulatory mechanisms, and genetic variants influencing adenosine metabolism. These discoveries have paved the way for investigating the therapeutic potential of targeting adenosine metabolism for the prevention and treatment of cardiovascular disorders.
This Research Topic seeks to explore the multifaceted roles of adenosine metabolism in cardiovascular and smooth muscle health and disease, aiming to shed light on the underlying mechanisms and identify novel therapeutic strategies. By bringing together research in molecular biology, physiology, pharmacology, and clinical studies, this Research Topic aims to unravel the complexities of adenosine metabolism and its potential as a therapeutic target in various cardiovascular conditions welcoming the submission of original research as well as review articles.
Keywords:
adenosine metabolism, adenosine, adenosine deaminase, nucleoside phosphorylases, molecular mechanisms
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.