About this Research Topic
Within the field of cardiovascular and smooth muscle health, adenosine is a key endogenous signaling molecule. Its regulatory functions are essential for maintaining homeostasis in these systems. Through interactions with adenosine receptors in various tissues, adenosine helps regulate vascular tone, affecting blood flow and cardiac contractility. Additionally, it plays a role in neuronal signaling and immune responses, both of which are critical for cardiovascular health. Disruptions in adenosine metabolism have been linked to several cardiovascular diseases, such as ischemic heart conditions, heart failure, and arrhythmias, highlighting the importance of further research in this area.
This Research Topic aims to explore the complex dynamics of adenosine metabolism and its impact on cardiovascular and smooth muscle health and disease. Our goal is to uncover the molecular mechanisms and receptor interactions of adenosine that influence disease progression and therapeutic outcomes. By understanding these processes, we can develop targeted therapeutic strategies that leverage the modulatory potential of adenosine in various disease contexts.
We invite articles that address, but are not limited to, the following themes:
• Molecular biology of adenosine receptors and their signaling pathways
• Impact of genetic variations on adenosine metabolism
• Novel enzymatic targets within adenosine metabolic pathways
• Therapeutic potentials of modulating adenosine activity
• Clinical outcomes of adenosine-based therapies
Through these contributions, this Research Topic seeks to enhance our understanding of the vital role adenosine plays in cardiovascular and smooth muscle health, with the potential to inform the development of innovative therapies.
This Research Topic aims to explore the complex dynamics of adenosine metabolism and its impact on cardiovascular and smooth muscle health and disease. Our goal is to uncover the molecular mechanisms and receptor interactions of adenosine that influence disease progression and therapeutic outcomes. By understanding these processes, we can develop targeted therapeutic strategies that leverage the modulatory potential of adenosine in various disease contexts.
We invite articles that address, but are not limited to, the following themes:
• Molecular biology of adenosine receptors and their signaling pathways
• Impact of genetic variations on adenosine metabolism
• Novel enzymatic targets within adenosine metabolic pathways
• Therapeutic potentials of modulating adenosine activity
• Clinical outcomes of adenosine-based therapies
Through these contributions, this Research Topic seeks to enhance our understanding of the vital role adenosine plays in cardiovascular and smooth muscle health, with the potential to inform the development of innovative therapies.
Keywords: adenosine metabolism, adenosine, adenosine deaminase, nucleoside phosphorylases, molecular mechanisms
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
