About this Research Topic
The progression of cancer arises as a consequence of disruptions within the cell signaling network, where multiple interconnected pathways collectively propel the behavior of tumor cells. Chemotherapy and immunotherapy stand as two principal therapeutic modalities; nevertheless, the intricacy of these signaling networks frequently hinders the success of targeted therapies at the individual molecular level. The cell signaling network, encompassing the intricate interactions between various signaling molecules and receptors within and between cells, forms the crux of comprehending the development and progression of cancer. Nonetheless, challenges such as drug resistance and tumor metastasis persist, underscoring the pressing need to explore novel approaches targeting key cell signaling networks for more effective cancer treatment. Immunotherapy, in particular, has captured significant attention as a disruptive approach. By stimulating the patient's immune system, it aims to impede the growth and dissemination of cancer cells. This process involves a myriad of signaling pathways, as well as the activation of immune cells such as NK cells and tumor-associated macrophages.100-150
While immunotherapy has achieved success in treating specific solid tumors, it confers significant benefits to only a minority of patients. Current research has identified numerous individual signaling pathways that influence cancer cell proliferation, metastasis, and drug resistance. Nonetheless, the complexity of signaling pathway networks constrains the successful clinical application of individual signaling molecules or gene targets. To address this challenge, an in-depth understanding of the functions and regulatory mechanisms of key signaling networks associated with tumor progression is essential, paving the way for the development of novel chemotherapeutic agents and targeted treatments.
This research initiative seeks to highlight recent advancements in the study of critical cell signaling networks within the context of cancer chemotherapy and immunotherapy. We welcome submissions in various forms, including original research, concise reviews, perspectives, and methodologies. The following topics are of particular interest, though not limited to:
1. Exploration of immune regulatory networks influencing cancer progression and prognosis.
2. Key signaling pathways involved in cancer initiation and metastasis.
3. Biomarkers predicting patient responses to immunotherapy and chemotherapy.
4. Understanding the crucial cell signaling networks influencing immune responses.
5. Utilizing single-cell genomics to unveil critical cancer signaling networks.
While immunotherapy has achieved success in treating specific solid tumors, it confers significant benefits to only a minority of patients. Current research has identified numerous individual signaling pathways that influence cancer cell proliferation, metastasis, and drug resistance. Nonetheless, the complexity of signaling pathway networks constrains the successful clinical application of individual signaling molecules or gene targets. To address this challenge, an in-depth understanding of the functions and regulatory mechanisms of key signaling networks associated with tumor progression is essential, paving the way for the development of novel chemotherapeutic agents and targeted treatments.
This research initiative seeks to highlight recent advancements in the study of critical cell signaling networks within the context of cancer chemotherapy and immunotherapy. We welcome submissions in various forms, including original research, concise reviews, perspectives, and methodologies. The following topics are of particular interest, though not limited to:
1. Exploration of immune regulatory networks influencing cancer progression and prognosis.
2. Key signaling pathways involved in cancer initiation and metastasis.
3. Biomarkers predicting patient responses to immunotherapy and chemotherapy.
4. Understanding the crucial cell signaling networks influencing immune responses.
5. Utilizing single-cell genomics to unveil critical cancer signaling networks.
Keywords: Cancer, Cellular Signaling Network, Immunotherapy, Chemotherapy, Immune
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
