About this Research Topic
Vulva cancer is a rare gynecological tumor, which occurs predominantly in women over 75 years of age. More than 45,000 new cases were diagnosed worldwide in 2020. This tumor is associated in most cases with human papillomavirus (HPV) infection, and in a small percentage with vulvar dermatosis, such as lichen sclerosus. Unfortunately, the symptomatology is often nuanced and the most frequent symptoms are in fact vulval pain, pruritus, bleeding and sometimes there is a lump or an ulcer.
To date, there are no screening programs that allow an early diagnosis so the rates of diagnosis in advanced stages remain not negligible. Surgery and radiotherapy are the methods used for the treatment of vulvar cancer, especially in the earliest stage; systemic chemotherapy is used in the most advanced forms and in relapses.
The surgical approach has evolved considerably over the years and has in fact gone from extensive and disfiguring vulvar resections with systematic inguinal lymphadenectomy to targeted and personalized surgical resection with the removal of sentinel lymph nodes bilaterally, with the aim of obtaining disease-free resection margins of at least 8 mm.
This special issue aims to examine the newest research on the diagnosis and treatment of vulvar cancer.
We are inviting Original Research articles, Review, Case Report, Clinical Trial, Hypothesis and Theory, Methods, Mini Review, Opinion, Perspective, Systematic Review, and Brief Research Reports to this Research Topic.
Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases that are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this topic.
To date, there are no screening programs that allow an early diagnosis so the rates of diagnosis in advanced stages remain not negligible. Surgery and radiotherapy are the methods used for the treatment of vulvar cancer, especially in the earliest stage; systemic chemotherapy is used in the most advanced forms and in relapses.
The surgical approach has evolved considerably over the years and has in fact gone from extensive and disfiguring vulvar resections with systematic inguinal lymphadenectomy to targeted and personalized surgical resection with the removal of sentinel lymph nodes bilaterally, with the aim of obtaining disease-free resection margins of at least 8 mm.
This special issue aims to examine the newest research on the diagnosis and treatment of vulvar cancer.
We are inviting Original Research articles, Review, Case Report, Clinical Trial, Hypothesis and Theory, Methods, Mini Review, Opinion, Perspective, Systematic Review, and Brief Research Reports to this Research Topic.
Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases that are not accompanied by robust and relevant validation (clinical cohort or biological validation in vitro or in vivo) are out of scope for this topic.
Keywords: Vulvar Cancer, Gynecologic Oncology, Vulvectomy, Tailored therapy, Vulvar disease
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
