About this Research Topic
Given the success of Volume I and Volume II of this Research Topic, and how rapidly the subject area is evolving, we are pleased to announce the launch of Volume III: Tumorigenesis Regulated by miRNAs.
In addition to tumor-related proteins and their coding genes, non-coding genes are also closely related to the occurrence and development of tumors. In particular, miRNAs, a class of highly conserved non-coding single-chain molecules, can inhibit gene expression at the post-transcriptional level by incomplete complementary pairing with the untranslated regions of multiple genes.
miRNAs are localized in tumor-related genomic regions and chromosome abnormalities can directly lead to changes in the copy number of miRNAs, thus resulting in an imbalance of expression in a variety of tumor-related genes. Therefore, miRNAs can promote or repress the expression of oncogenes or tumor-suppressor genes. These abnormal expressions detected in almost all tumor tissues can reflect their tissue origin and can be used for molecular typing of tumors. Previous studies demonstrate that miRNAs participate in almost every step in the occurrence and development of tumors and play an important role in tumor pathogenesis.
Consequently, this topic aims to exploit novel miRNAs that could regulate the expression of tumor-related genes, thus controlling the occurrence and progress of tumors. Meanwhile, the cellular, molecular, and pathogenic mechanism of tumorigenesis regulation by miRNA is also to be elucidated in this topic.
We welcome the following submissions covering:
• miRNAs that could promote/repress tumorigenesis and their mechanisms
• The exploitation of miRNAs used for tumor diagnosis by bioinformatics and the demonstration of their function
• Applications of miRNAs to control the occurrence and progress of tumors, and how they may affect human health
•Progress of miRNA in tumor molecular diagnosis and treatment
Dr. Guangchao Li receives funding from Guangzhou Baiji Gene Technology Co., LTD, and all other Topic Editors declare no conflicts of interest.
In addition to tumor-related proteins and their coding genes, non-coding genes are also closely related to the occurrence and development of tumors. In particular, miRNAs, a class of highly conserved non-coding single-chain molecules, can inhibit gene expression at the post-transcriptional level by incomplete complementary pairing with the untranslated regions of multiple genes.
miRNAs are localized in tumor-related genomic regions and chromosome abnormalities can directly lead to changes in the copy number of miRNAs, thus resulting in an imbalance of expression in a variety of tumor-related genes. Therefore, miRNAs can promote or repress the expression of oncogenes or tumor-suppressor genes. These abnormal expressions detected in almost all tumor tissues can reflect their tissue origin and can be used for molecular typing of tumors. Previous studies demonstrate that miRNAs participate in almost every step in the occurrence and development of tumors and play an important role in tumor pathogenesis.
Consequently, this topic aims to exploit novel miRNAs that could regulate the expression of tumor-related genes, thus controlling the occurrence and progress of tumors. Meanwhile, the cellular, molecular, and pathogenic mechanism of tumorigenesis regulation by miRNA is also to be elucidated in this topic.
We welcome the following submissions covering:
• miRNAs that could promote/repress tumorigenesis and their mechanisms
• The exploitation of miRNAs used for tumor diagnosis by bioinformatics and the demonstration of their function
• Applications of miRNAs to control the occurrence and progress of tumors, and how they may affect human health
•Progress of miRNA in tumor molecular diagnosis and treatment
Dr. Guangchao Li receives funding from Guangzhou Baiji Gene Technology Co., LTD, and all other Topic Editors declare no conflicts of interest.
Keywords: miRNA, regulation, Stemness of cancer cell, Overexpression, Gene knock-out, Tumorigenesis
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
