About this Research Topic
From sensory to motor, and cognitive domains, the trace of brain oscillations can be found in nearly every brain function. Abnormal oscillatory patterns have been linked to several brain disorders such as Alzheimer's disease, Parkinson’s disease, essential tremor, dystonia, epilepsy, tinnitus, attention deficit hyperactivity disorder, and autism spectrum disorder. Neuromodulation provides interventional tools to modify brain oscillations and/or induce therapeutic effects. For instance, brain oscillations can be modulated by a variety of invasive and noninvasive neuromodulation paradigms, including deep brain stimulation (DBS), transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS), transcranial magnetic stimulation (TMS) and repetitive transcranial magnetic stimulation (rTMS). Yet, the underlying mechanisms of therapeutic action remain poorly understood.
A crucial aspect for clinical translation concerns whether neuromodulatory effects outlast the duration of administration. Recent findings suggested that plasticity may be one of the key mechanisms behind the durable effects of neuromodulation on brain oscillations. In general, plasticity refers to the brain's ability to change and adapt, including its ability to modify brain oscillations. This can have therapeutic effects, as it allows the brain to reorganize and recover from injury or disease. Neuromodulation techniques can be used to harness plasticity and induce beneficial changes in brain activity and connectivity. In fact, promoting synaptic plasticity improves communication within local networks as well as between distant regions by remodeling neuronal activity and synaptic connectivity patterns.
While a substantial amount of work has been devoted to pre-clinical (animal) and clinical aspects of neuromodulation, predictions of computational modeling studies offer testable hypotheses for enhancing neuromodulation techniques. This research topic aims to explore how targeting plasticity via different neuromodulation paradigms may improve brain function by modulating brain oscillations. This includes pre-clinical and clinical studies, as well as computational modeling of brain oscillations and changes in plasticity mechanisms across various scales, from microcircuits to large-scale networks, with the capability to inspire experimental work.
This research topic is open to theoretical/computational, pre-clinical and clinical studies. Original research articles, review articles as well as opinion and perspective articles related to modulation that targets plasticity to modify brain oscillations and/or induce therapeutic effects are welcomed. Topics of interest include but are not limited to:
• Modulation of brain oscillations and its implication for neurorehabilitation,
• Brain oscillations as biomarkers for monitoring treatment efficacy in brain disorders,
• Changes in brain oscillations following plastic reshaping of neuronal circuits,
• Plasticity mechanisms underlying long-lasting neuromodulatory effects,
• Entrainment of oscillations and its interplay with plasticity effects,
• Basic mechanisms of network oscillations in the brain,
• Response of neuronal circuits to electrical, magnetic or sensory stimulation,
• Multistability in plastic networks and computational models of brain disorders.
We expect the contributions will refine our understanding of the mechanisms by which neuromodulation paradigms interact with neuronal circuits to reshape brain oscillations in order to improve brain functions in health and disease.
A crucial aspect for clinical translation concerns whether neuromodulatory effects outlast the duration of administration. Recent findings suggested that plasticity may be one of the key mechanisms behind the durable effects of neuromodulation on brain oscillations. In general, plasticity refers to the brain's ability to change and adapt, including its ability to modify brain oscillations. This can have therapeutic effects, as it allows the brain to reorganize and recover from injury or disease. Neuromodulation techniques can be used to harness plasticity and induce beneficial changes in brain activity and connectivity. In fact, promoting synaptic plasticity improves communication within local networks as well as between distant regions by remodeling neuronal activity and synaptic connectivity patterns.
While a substantial amount of work has been devoted to pre-clinical (animal) and clinical aspects of neuromodulation, predictions of computational modeling studies offer testable hypotheses for enhancing neuromodulation techniques. This research topic aims to explore how targeting plasticity via different neuromodulation paradigms may improve brain function by modulating brain oscillations. This includes pre-clinical and clinical studies, as well as computational modeling of brain oscillations and changes in plasticity mechanisms across various scales, from microcircuits to large-scale networks, with the capability to inspire experimental work.
This research topic is open to theoretical/computational, pre-clinical and clinical studies. Original research articles, review articles as well as opinion and perspective articles related to modulation that targets plasticity to modify brain oscillations and/or induce therapeutic effects are welcomed. Topics of interest include but are not limited to:
• Modulation of brain oscillations and its implication for neurorehabilitation,
• Brain oscillations as biomarkers for monitoring treatment efficacy in brain disorders,
• Changes in brain oscillations following plastic reshaping of neuronal circuits,
• Plasticity mechanisms underlying long-lasting neuromodulatory effects,
• Entrainment of oscillations and its interplay with plasticity effects,
• Basic mechanisms of network oscillations in the brain,
• Response of neuronal circuits to electrical, magnetic or sensory stimulation,
• Multistability in plastic networks and computational models of brain disorders.
We expect the contributions will refine our understanding of the mechanisms by which neuromodulation paradigms interact with neuronal circuits to reshape brain oscillations in order to improve brain functions in health and disease.
Keywords: brain oscillations, network physiology, neuroplasticity, brain disorders, neuromodulation, brain stimulation, synaptic plasticity, structural plasticity, homeostatic plasticity, synchronization, network models.
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