About this Research Topic
The human brain is a complex and enigmatic organ within the body, serving as the epicenter of our thoughts, emotions, memories, and behaviors. It is a heterogeneous tissue that rapidly adapts to changes in the environment and orchestrates a myriad of functions, ranging from basic physiological processes to the most advanced cognitive functions. The interplay between environmental factors and genetic variation in the brain explains biological differences among individuals and may be modulated by epigenetic mechanisms, including DNA methylation.
Several studies have suggested changes in epigenetic mechanisms associated with neurodegenerative disorders, such as Alzheimer's, Huntington's, Parkinson's disease, and psychiatric disorders, including substance use disorders and post-traumatic stress disorder, among others. In this research topic, our aim is to elucidate the dynamic patterns of methylation in the human brain and their implications for brain development, function, and neurological disorders. Additionally, we seek to discuss the role of DNA methylation in the human brain, spanning from basic science to disease development, while taking a cross-tissue and cross-population perspective.
We welcome original research, review article, systematic review, meta-analysis, clinical case studies and new ideas related, but not limited, to the following topics:
•Relationship between brain activity and genomics
•Research related to human brain samples
•DNA methylation studies
•Multi-omics study focusing on genetics and metabolism
•Interest in cross-tissue studies
•Subtype-specific genetic networks in neurodevelopmental or psychiatric disorders
•Interest in studies applying computational biology and bioinformatics
•Cross-population studies are strongly encouraged
Several studies have suggested changes in epigenetic mechanisms associated with neurodegenerative disorders, such as Alzheimer's, Huntington's, Parkinson's disease, and psychiatric disorders, including substance use disorders and post-traumatic stress disorder, among others. In this research topic, our aim is to elucidate the dynamic patterns of methylation in the human brain and their implications for brain development, function, and neurological disorders. Additionally, we seek to discuss the role of DNA methylation in the human brain, spanning from basic science to disease development, while taking a cross-tissue and cross-population perspective.
We welcome original research, review article, systematic review, meta-analysis, clinical case studies and new ideas related, but not limited, to the following topics:
•Relationship between brain activity and genomics
•Research related to human brain samples
•DNA methylation studies
•Multi-omics study focusing on genetics and metabolism
•Interest in cross-tissue studies
•Subtype-specific genetic networks in neurodevelopmental or psychiatric disorders
•Interest in studies applying computational biology and bioinformatics
•Cross-population studies are strongly encouraged
Keywords: DNA Methylation, Epigenetics, Brain Development, Neuroepigenetics, Omics
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
