About this Research Topic
Cholera is a dreadful dehydrating diarrhoeal disease, that poses a great public health threat globally leading to large morbidity and substantial mortality. It’s mainly associated with inadequate sanitation and poor hygiene, lack of access to safe drinking water, overcrowding
and poverty. The World Health Organization (WHO) estimates that globally there are 1.3 to 4.0 million cases of cholera, and 21 000 to 143 000 deaths worldwide, out of which only a small fraction is officially reported.
Although rehydration therapy is the primary treatment, treatment with antibiotic reduces the volume of stool, duration and frequency of diarrhoea. Currently escalating increase of antibiotic resistance has created alarming situation that proposes for alternative drug therapy,
modification of drugs or search for new drugs. Epidemiological understanding of V. cholerae narrates its transmission, distribution, and public health importance. Additionally molecular epidemiological study of V. cholerae depicts the distribution of genotypes which in turn discloses genetic diversity, virulence factor, and transmission dynamics. This will help in tracking its origin and spread, facilitating for implementation of control measures and intervention.
From the history of cholera and recent scientific analysis it can be presumed that evolution of V. cholerae will remain on changing mode due to the sequential modification in its genome which will influence in virulence, transmission and spread. An effective constant surveillance is suggested to act as a resource to develop early warning to implement prevention and preparedness for disease outbreak in endemic areas all around the globe.
We invite researchers to submit studies that address the molecular mechanisms of V. cholerae virulence, the ecological dynamics of cholera outbreaks, novel diagnostic methods, vaccine development, and innovative therapeutic approaches. By bringing together a diverse array of research, we seek to foster a comprehensive understanding of cholera and contribute to global efforts to control and eventually eradicate this deadly disease. Topics of Interest Include but Are Not Limited To:
• Gene regulation and expression related to virulence factors.
• Mechanisms of host-pathogen interactions.
• Environmental factors influencing V. cholerae pathogenicity
• Advances in surveillance methods and early warning systems.
• Genomic insights from outbreak strains.
• Reservoirs and transmission dynamics in aquatic environments.
• Role of biofilms in V. cholerae persistence.
• Development of rapid and accurate diagnostic tools.
• Antimicrobial resistance trends and novel treatment options.
and poverty. The World Health Organization (WHO) estimates that globally there are 1.3 to 4.0 million cases of cholera, and 21 000 to 143 000 deaths worldwide, out of which only a small fraction is officially reported.
Although rehydration therapy is the primary treatment, treatment with antibiotic reduces the volume of stool, duration and frequency of diarrhoea. Currently escalating increase of antibiotic resistance has created alarming situation that proposes for alternative drug therapy,
modification of drugs or search for new drugs. Epidemiological understanding of V. cholerae narrates its transmission, distribution, and public health importance. Additionally molecular epidemiological study of V. cholerae depicts the distribution of genotypes which in turn discloses genetic diversity, virulence factor, and transmission dynamics. This will help in tracking its origin and spread, facilitating for implementation of control measures and intervention.
From the history of cholera and recent scientific analysis it can be presumed that evolution of V. cholerae will remain on changing mode due to the sequential modification in its genome which will influence in virulence, transmission and spread. An effective constant surveillance is suggested to act as a resource to develop early warning to implement prevention and preparedness for disease outbreak in endemic areas all around the globe.
We invite researchers to submit studies that address the molecular mechanisms of V. cholerae virulence, the ecological dynamics of cholera outbreaks, novel diagnostic methods, vaccine development, and innovative therapeutic approaches. By bringing together a diverse array of research, we seek to foster a comprehensive understanding of cholera and contribute to global efforts to control and eventually eradicate this deadly disease. Topics of Interest Include but Are Not Limited To:
• Gene regulation and expression related to virulence factors.
• Mechanisms of host-pathogen interactions.
• Environmental factors influencing V. cholerae pathogenicity
• Advances in surveillance methods and early warning systems.
• Genomic insights from outbreak strains.
• Reservoirs and transmission dynamics in aquatic environments.
• Role of biofilms in V. cholerae persistence.
• Development of rapid and accurate diagnostic tools.
• Antimicrobial resistance trends and novel treatment options.
Keywords: Cholera, V. cholerae O1, V. cholerae O139, V. cholerae non O1 and non-O139, ctxB variants, Hitian variants, cholera toxin (ctxA), tcpA, toxR, wbe, wbf, zot, ace
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