About this Research Topic
Traumatic brain injury (TBI) is a significant health concern worldwide, often resulting from accidents, sports-related injuries, or military service. While the immediate consequences of TBI are well known, emerging evidence suggests that it can also trigger or facilitate the development of neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), or chronic traumatic encephalopathy (CTE). This Research Topic aims to investigate the underlying mechanisms that link TBI to earlier onset or enhanced progression of neurodegeneration and identify potential therapeutic targets for intervention.
This Research Topic invites contributions that explore the complex relationship between TBI and neurodegenerative diseases, elucidating the mechanisms responsible for accelerating or exacerbating neurodegenerative processes following TBI. It welcomes research from diverse disciplines, including neuroepidemiology, neuroscience, neurology, psychiatry, neuropathology, molecular biology, and clinical medicine. Studies utilizing animal models, human samples, imaging techniques, and clinical investigations are encouraged to shed light on the molecular and cellular mechanisms driving this association.
To capture the spectrum of TBI complications, this topic is narrowly tailored to focus on the intersection between traumatic brain injury and subsequent neurodegenerative effects. We especially welcome contributions that provide a comprehensive look into:
-Molecular and cellular responses to TBI that expedite neurodegenerative diseases
-Innovative approaches to identify and evaluate biomarkers for early detection of neurodegeneration post-TBI
-Mechanistic studies on neuroinflammation, protein misfolding, synaptic disruptions, and neuronal loss
-Therapeutic research focusing on alleviating the neuropathological consequences of traumatic brain injuries
-Translational studies that bridge experimental research to clinical implications
The goal of this Research Topic is to synthesize current insights, foster interdisciplinary collaboration, and spur innovations that might ultimately lead to effective preventive or corrective therapies for TBI-induced neurodegeneration.
This Research Topic invites contributions that explore the complex relationship between TBI and neurodegenerative diseases, elucidating the mechanisms responsible for accelerating or exacerbating neurodegenerative processes following TBI. It welcomes research from diverse disciplines, including neuroepidemiology, neuroscience, neurology, psychiatry, neuropathology, molecular biology, and clinical medicine. Studies utilizing animal models, human samples, imaging techniques, and clinical investigations are encouraged to shed light on the molecular and cellular mechanisms driving this association.
To capture the spectrum of TBI complications, this topic is narrowly tailored to focus on the intersection between traumatic brain injury and subsequent neurodegenerative effects. We especially welcome contributions that provide a comprehensive look into:
-Molecular and cellular responses to TBI that expedite neurodegenerative diseases
-Innovative approaches to identify and evaluate biomarkers for early detection of neurodegeneration post-TBI
-Mechanistic studies on neuroinflammation, protein misfolding, synaptic disruptions, and neuronal loss
-Therapeutic research focusing on alleviating the neuropathological consequences of traumatic brain injuries
-Translational studies that bridge experimental research to clinical implications
The goal of this Research Topic is to synthesize current insights, foster interdisciplinary collaboration, and spur innovations that might ultimately lead to effective preventive or corrective therapies for TBI-induced neurodegeneration.
Keywords: blast-injury, secondary-TBI mechanisms, axonal traumatic damage, neuroinflammation, chronic traumatic encephalopathy, behavioral changes., Head trauma, Concussion, Neurocognitive disorder, Biomarkers, Neuroimaging, Therapeutic strategy, Alzheimer's disease, Parkinson's disease
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
