About this Research Topic
Aberrations in cancer epigenomics encompass a wide range of chromatin alterations. Low DNA methylation is commonly observed in the genome of tumor cells, which increases genomic instability and promotes the occurrence of tumors. Histone modifications, such as acetylation, methylation, phosphorylation, and ubiquitination, are associated with abnormal gene expression in tumors. Chromatin recombination regulates gene transcription, participate in cellular physiological processes, and is closely related to tumor development. Non coding DNA mainly includes IncRNA, miRNA, circRNA, etc., and plays an important role in gene expression regulation. Due to the reversibility of epigenetics, drugs targeting epigenetics provide new directions and strategies for the treatment of solid tumors. Currently, common types of drugs include DNA methyltransferase inhibitors and histone deacetylase inhibitors. Furthermore, targeting other epigenetic modifications such as histone methyltransferases and demethylases has shown promise in cancer therapy. In addition, the combination of epigenetic drugs and various anti-tumor drugs have broad application prospects. Further exploration of the mechanism of epigenetics in solid tumor is expected to develop novel therapeutic targets and targeted drugs for patients with solid tumor.
Understanding novel biomarkers, unraveling epigenetics-related molecular mechanisms, identifying therapeutic targets, and exploring targeted therapeutic drugs are pivotal aspects contributing to the enhanced prognosis of patients with various solid tumors, including breast cancer, lung cancer, gastroenteric tumors, liver cancer, and hematological malignancies. This research aims to delve deeper into the intricate role of epigenetics in the genesis of solid tumors and to assess the potential of epigenetic drugs as a targeted approach for the treatment of these malignancies.
We welcome contributions of Original Research, Special Topic Abstract, Systematic Review, Methods, Review, Mini Review, Hypothesis and Theory encompassing clinical, translational, and basic researches focusing on novel molecular mechanisms and clinical strategies about epigenetics and epigenomics in solid tumor. Topics of interest include, but not limited to, the following aspects:
• Epigenetic and molecular mechanisms of solid tumor development
• Epigenetic regulation of tumor microenvironment
• RNA-seq, Single-cell RNA-seq, Single nucleus RNA-seq, Spatial transcriptome, Proteomics.
• Non-coding RNAs (miRNAs, LncRNAs, CircRNAs) and epigenetic regulation
• Cancer epigenetics in novel therapeutic targets and clinical strategies
Understanding novel biomarkers, unraveling epigenetics-related molecular mechanisms, identifying therapeutic targets, and exploring targeted therapeutic drugs are pivotal aspects contributing to the enhanced prognosis of patients with various solid tumors, including breast cancer, lung cancer, gastroenteric tumors, liver cancer, and hematological malignancies. This research aims to delve deeper into the intricate role of epigenetics in the genesis of solid tumors and to assess the potential of epigenetic drugs as a targeted approach for the treatment of these malignancies.
We welcome contributions of Original Research, Special Topic Abstract, Systematic Review, Methods, Review, Mini Review, Hypothesis and Theory encompassing clinical, translational, and basic researches focusing on novel molecular mechanisms and clinical strategies about epigenetics and epigenomics in solid tumor. Topics of interest include, but not limited to, the following aspects:
• Epigenetic and molecular mechanisms of solid tumor development
• Epigenetic regulation of tumor microenvironment
• RNA-seq, Single-cell RNA-seq, Single nucleus RNA-seq, Spatial transcriptome, Proteomics.
• Non-coding RNAs (miRNAs, LncRNAs, CircRNAs) and epigenetic regulation
• Cancer epigenetics in novel therapeutic targets and clinical strategies
Keywords: Epigenetic regulation of tumor microenvironment • RNA-seq, Single-cell RNA-seq, Single nucleus RNA-seq, Spatial transcriptome, Proteomics. • Non-coding RNAs (miRNAs, LncRNAs, CircRNAs) and epigenetic regulation •
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