About this Research Topic
The inhibitory immune microenvironment and tumor heterogeneity of glioblastoma are key reasons for treatment failure and tumor recurrence. Therefore, it is crucial to explore the features of the glioblastoma microenvironment, identify innovative prognostic or predictive biomarkers, and develop novel therapeutic strategies to reverse the inhibitory immune microenvironment. In addition to glioblastoma-focused studies, comparative studies investigating the immune microenvironment of other central nervous system (CNS) tumors will also provide valuable perspectives for us to further understand the immune microenvironment of CNS tumors.
We welcome both Original Research and Review articles within the scope of the Research Topic. Studies focusing on the following key points are of great interest:
(1) Exploration of innovative tumor biomarkers that will contribute to uncovering the immune microenvironment of glioblastoma and other CNS tumors.
(2) Investigation of tumor heterogeneity and the immune microenvironment in glioblastoma through advanced research techniques, including single-cell sequencing, spatial transcriptome analysis, ATAC sequencing, m6A methylation analysis, and metabolomics analysis.
(3) Identification and validation of novel function or cell subtypes of immune cells within tumor immune microenvironment, especially for tumor-associated macrophages and microglia.
(4) Depicting the landscape of unique extracellular matrix and relevant stromal cells that correlate with malignant biological phenotype.
(5) Development of novel therapeutic strategies to reverse immunosuppressive microenvironment or target brain tumor cells. Interpretation of the underlying mechanisms related to anti-tumor therapies.
Please Note: Manuscripts only consisting of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (multi-clinical cohort analysis or biological function experiments) are out of scope for this section.
Keywords: Therapeutic Strategy, Cerebral Glioblastoma, tumor immune microenvironment
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.