About this Research Topic
While retroviruses within the genus Lentivirus are typically associated with immunodeficiency, retroviruses belonging to the genera Alpha-, Beta-, Gamma-, Delta-, and Epsilon-retrovirus induce tumors, such as sarcomas and leukemia. The evolutionary mechanisms of why they cause specific tumors or immunodeficiency across species have not been fully elucidated. After infection, these viruses are reverse transcribed by viral reverse transcriptase (RT), and double-stranded DNA is integrated into the host genome. Conversely, it is not known why the genera Retroviruses cause tumors and genus Lentivirus causes immunodeficiency, despite having very similar viral genomic structures and life cycles. The distinct research territories and the lack of information exchange among researchers also hinder a better understanding of viral pathogenicity in retroviruses.
Consequently, the goal of this Research Topic is to collect Original Research and Reviews from a wide range of research on retroviruses, thus, providing and sharing the latest information on frontline retrovirology. By sharing information and learning about viruses of other species belonging to the same subfamily, we hope to help researchers in this field worldwide accelerate the understanding of viruses within this field.
This Research Topic welcomes Original Research and Reviews of the latest investigation on retroviruses regardless of infected host species. In particular, we are keen on research on various aspects from infection to disease development, which include cellular and molecular biology of viral products, genomic and epigenomic analysis of host cells, host-virus interactions, infectious immunity, and mechanisms of virulence expression. In addition, we welcome submissions on the leading edge of countermeasures for humans and animals against diseases triggered by these viral infections. This encompasses the latest information on the development of vaccines, prevention of disease onset by effective removal of infected cells from carriers, and innovative new therapeutic approaches for cure after the onset of diseases.
Consequently, the goal of this Research Topic is to collect Original Research and Reviews from a wide range of research on retroviruses, thus, providing and sharing the latest information on frontline retrovirology. By sharing information and learning about viruses of other species belonging to the same subfamily, we hope to help researchers in this field worldwide accelerate the understanding of viruses within this field.
This Research Topic welcomes Original Research and Reviews of the latest investigation on retroviruses regardless of infected host species. In particular, we are keen on research on various aspects from infection to disease development, which include cellular and molecular biology of viral products, genomic and epigenomic analysis of host cells, host-virus interactions, infectious immunity, and mechanisms of virulence expression. In addition, we welcome submissions on the leading edge of countermeasures for humans and animals against diseases triggered by these viral infections. This encompasses the latest information on the development of vaccines, prevention of disease onset by effective removal of infected cells from carriers, and innovative new therapeutic approaches for cure after the onset of diseases.
Keywords: orthoretrovirinae, retroviridae, life-threating viruses, host-virus interactions, therapeutic strategies
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
