Complex, bidirectional signalling between neurons and immune cells regulates the normal development and homeostasis of all biological systems. However, neuro-immune interactions also contribute to the initiation, pathology, and treatment resistance of diverse diseases, including some of the leading causes of human morbidity and mortality such as cardiac ischemia, stroke, cancer, neurodegeneration, and psychiatric conditions. Recently, drugs that specifically modulate neuro-immune interactions have shown promising results for a number of indications, spurring a flurry of research to better understand the role of the neuro-immune axis in health and disease, and identify novel, druggable targets.
This Research Topic will highlight some of the cutting-edge biology, chemistry, technologies, research methodology, and clinical breakthroughs that are advancing our understanding and ability to modulate the neuro-immune axis, provide a perspective on current limitations in the field, and a vision for the future trajectory of leveraging the neuro-immune interactions for therapeutic development.
At least 50% of articles accepted for this topic will be Original Research, including that describing Methods, Case Reports, or Clinical Trials. However, this topic also welcomes submissions of the following article types: Editorial, General Commentary, Mini Review, Opinion, Perspective, and Review.
This Research Topic welcomes manuscripts covering, but not limited to the following themes:
1. Mechanisms of neuro-immune interactions in health and disease; including insights from biological, biochemical, genetic, clinical, and epidemiological studies; and relating to diverse disease areas, including neurodegeneration, cardiovascular disease, oncology, psychiatric disease, post-viral syndromes, microbiome, etc.
2. The identification of novel drug targets to modulate the neuro-immune axis
3. The discovery and/or synthesis of new chemical entities targeting the neuro-immune axis; including hit discovery, medicinal chemistry, structure-activity relationship studies, natural products, and structural characterization.
4. Non-chemical approaches to target the neuro-immune axis, including biologics, cell-based therapies, vaccines, and non-pharmaceutical/lifestyle interventions.
5. Clinical trials
6. New technologies or research methodology driving forward our understanding and ability to target the neuro-immune axis; including imaging agents, "omics" technologies, disease models, etc.
Keywords:
Drug, immune, neuron, chemistry, pharmacology, CNS, chemical probe, molecular, therapeutic, Neuro-Immune Axis
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Complex, bidirectional signalling between neurons and immune cells regulates the normal development and homeostasis of all biological systems. However, neuro-immune interactions also contribute to the initiation, pathology, and treatment resistance of diverse diseases, including some of the leading causes of human morbidity and mortality such as cardiac ischemia, stroke, cancer, neurodegeneration, and psychiatric conditions. Recently, drugs that specifically modulate neuro-immune interactions have shown promising results for a number of indications, spurring a flurry of research to better understand the role of the neuro-immune axis in health and disease, and identify novel, druggable targets.
This Research Topic will highlight some of the cutting-edge biology, chemistry, technologies, research methodology, and clinical breakthroughs that are advancing our understanding and ability to modulate the neuro-immune axis, provide a perspective on current limitations in the field, and a vision for the future trajectory of leveraging the neuro-immune interactions for therapeutic development.
At least 50% of articles accepted for this topic will be Original Research, including that describing Methods, Case Reports, or Clinical Trials. However, this topic also welcomes submissions of the following article types: Editorial, General Commentary, Mini Review, Opinion, Perspective, and Review.
This Research Topic welcomes manuscripts covering, but not limited to the following themes:
1. Mechanisms of neuro-immune interactions in health and disease; including insights from biological, biochemical, genetic, clinical, and epidemiological studies; and relating to diverse disease areas, including neurodegeneration, cardiovascular disease, oncology, psychiatric disease, post-viral syndromes, microbiome, etc.
2. The identification of novel drug targets to modulate the neuro-immune axis
3. The discovery and/or synthesis of new chemical entities targeting the neuro-immune axis; including hit discovery, medicinal chemistry, structure-activity relationship studies, natural products, and structural characterization.
4. Non-chemical approaches to target the neuro-immune axis, including biologics, cell-based therapies, vaccines, and non-pharmaceutical/lifestyle interventions.
5. Clinical trials
6. New technologies or research methodology driving forward our understanding and ability to target the neuro-immune axis; including imaging agents, "omics" technologies, disease models, etc.
Keywords:
Drug, immune, neuron, chemistry, pharmacology, CNS, chemical probe, molecular, therapeutic, Neuro-Immune Axis
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.