Metabolism, Gut Microbiome, and Cancer

Abnormal metabolic alterations play critical roles in tumorigenesis. Targeting cancer metabolism can provide novel diagnostic biomarkers and intervention targets for cancer research. The gut microbiome refers to the complex community of microorganisms that reside in the human gastrointestinal tract. It has been well-accepted that the gut microbiome plays an important role in supporting overall health and a robust immune system. The gut microbiome has been implicated in cancer development and shown to modulate anticancer drug efficacy. Gut microbiota-derived metabolites are key hubs connecting the gut microbiome and cancer progression and treatment. Interventions on the gut microbiota and key microbial metabolites can exert anti-cancer effects through the regulation of host immune functions and metabolism. This has become a new area of interest in cancer prevention and treatment, with potential therapies aiming at specific gut microbiota, microbial metabolites, and cancer metabolism.

The purpose of this Research Topic is to focus on the advances of the association between gut microbiota, microbial-derived metabolites, and cancer metabolism, and discuss how potential novel interventions derived from this area will help to improve cancer prevention and treatment.

We welcome the submission of Review or Original Research papers focusing on, but not limited to, the following areas:
-Gut microbiota and cancer development, therapy and prevention
-Microbial metabolites and cancer therapy
-Metabolic disorders/diseases, immune and cancer
-Cancer metabolism and therapy
-Diet/nutrition, metabolism and cancer prevention

Please note: Manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.