About this Research Topic
Mendelian randomization (MR) represents a valuable methodology to address the causal relationships between an exposure and an outcome. In MR studies, instrumental variables associated with the exposure are carefully selected, with alleles being randomly assigned according to Mendel's second law of inheritance. Analogous to a natural randomized clinical trial (RCT), the MR methodology enables researchers to circumvent potential confounding variables and offers unique advantages in elucidating the causal relationship between risk factors and outcomes, particularly in understanding the causal relationship between risk factors and cardiovascular diseases.
Previous MR studies have provided robust evidence of the strong associations between certain risk factors and cardiovascular diseases. For instance, conclusive causal relationships have been established between sleep apnea and hypertension. However, there remain gaps in our understanding of causal relationships between some risk factors and cardiovascular diseases. For example, the causality between sleep apnea and pulmonary artery hypertension has yet to be established. The lack of precise causality hampers our abilities to comprehensively investigate etiology, pathophysiology, measurement techniques, and potential therapies for cardiovascular diseases. Thus, it is imperative to analyze the causality between risk factors and cardiovascular diseases using MR or alternative methodologies. In addition, the presence of mediating factors in the pathogenesis of risk factor-induced cardiovascular diseases requires further investigation.
In this Research Topic, we welcome researchers to submit original research articles and review articles that will contribute to the field of the causality between risk factors and cardiovascular diseases, with a special emphasis on MR studies. We welcome clinical studies and pooled analyses focusing on the etiology, pathophysiology, measurement approaches, and therapeutic interventions for cardiovascular diseases, including pulmonary artery hypertension, coronary artery disease, and chronic heart failure. This Research Topic is interested in the following research fields, but not limited to:
• MR studies investigating the causality between oxidative stress, inflammation, hypoxia, metabolic abnormalities and other risk factors, and various cardiovascular diseases, including hypertension, coronary artery disease, chronic heart failure, atrial fibrillation, pulmonary artery hypertension, and more.
• Other effective analytical methods or clinical studies examining the causality between risk factors and cardiovascular diseases.
Previous MR studies have provided robust evidence of the strong associations between certain risk factors and cardiovascular diseases. For instance, conclusive causal relationships have been established between sleep apnea and hypertension. However, there remain gaps in our understanding of causal relationships between some risk factors and cardiovascular diseases. For example, the causality between sleep apnea and pulmonary artery hypertension has yet to be established. The lack of precise causality hampers our abilities to comprehensively investigate etiology, pathophysiology, measurement techniques, and potential therapies for cardiovascular diseases. Thus, it is imperative to analyze the causality between risk factors and cardiovascular diseases using MR or alternative methodologies. In addition, the presence of mediating factors in the pathogenesis of risk factor-induced cardiovascular diseases requires further investigation.
In this Research Topic, we welcome researchers to submit original research articles and review articles that will contribute to the field of the causality between risk factors and cardiovascular diseases, with a special emphasis on MR studies. We welcome clinical studies and pooled analyses focusing on the etiology, pathophysiology, measurement approaches, and therapeutic interventions for cardiovascular diseases, including pulmonary artery hypertension, coronary artery disease, and chronic heart failure. This Research Topic is interested in the following research fields, but not limited to:
• MR studies investigating the causality between oxidative stress, inflammation, hypoxia, metabolic abnormalities and other risk factors, and various cardiovascular diseases, including hypertension, coronary artery disease, chronic heart failure, atrial fibrillation, pulmonary artery hypertension, and more.
• Other effective analytical methods or clinical studies examining the causality between risk factors and cardiovascular diseases.
Keywords: mendelian randomization, inverse-variance weighted, cardiovascular diseases, pulmonary artery hypertension, coronary artery disease, heart failure
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