About this Research Topic
Nephrotic syndrome, the leading glomerular disease in children and adults, primarily occurs due to damage to the glomerular basement membrane and the podocyte - a specialized epithelial cell within the glomerulus. This condition is characterized by proteinuria, edema, and hypoalbuminemia. The worldwide prevalence of nephrotic syndrome in children is 16/100,000, although it does vary among different population groups. Furthermore, there are variations in kidney morphological changes, disease severity, and response to therapy.
Focal segmental glomerulosclerosis (FSGS) is the most common pathology among adults of African descent, while Membranous nephropathy (MN) tends to be more common in Caucasians. Children, on the other hand, most often present with Minimal change disease (MCD). The incidence of nephrotic syndrome is higher in children of African and Asian descent, and African American and Hispanic children tend to be more resistant to treatment and experience poorer outcomes.
These disparities are believed to result from a combination of multifactorial causes, influenced by both environmental and genetic factors. The aim of this special topic issue is to shed light on the various risk factors and causes that contribute to the differing outcomes observed in nephrotic syndrome patients worldwide.
This research topic will explore the factors contributing to outcome disparities, delving into the issue at various levels and describing their interconnections. The thematic areas encompass socio-economic factors such as wealth and education, patient factors including ethnicity, ancestry, and genetic variation, as well as healthcare factors such as barriers to access. We welcome submissions in the form of reviews, perspectives, original research, research reports, opinion pieces, methods papers, and clinical trials.
Focal segmental glomerulosclerosis (FSGS) is the most common pathology among adults of African descent, while Membranous nephropathy (MN) tends to be more common in Caucasians. Children, on the other hand, most often present with Minimal change disease (MCD). The incidence of nephrotic syndrome is higher in children of African and Asian descent, and African American and Hispanic children tend to be more resistant to treatment and experience poorer outcomes.
These disparities are believed to result from a combination of multifactorial causes, influenced by both environmental and genetic factors. The aim of this special topic issue is to shed light on the various risk factors and causes that contribute to the differing outcomes observed in nephrotic syndrome patients worldwide.
This research topic will explore the factors contributing to outcome disparities, delving into the issue at various levels and describing their interconnections. The thematic areas encompass socio-economic factors such as wealth and education, patient factors including ethnicity, ancestry, and genetic variation, as well as healthcare factors such as barriers to access. We welcome submissions in the form of reviews, perspectives, original research, research reports, opinion pieces, methods papers, and clinical trials.
Keywords: Nephrotic syndrome, glomerular disease, glomerular basement membrane, Focal segmental glomerulosclerosis, Membranous nephropathy, Minimal change disease, worldwide prevalence
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