About this Research Topic
The field of gasotransmitter research has emerged as a dynamic and interdisciplinary domain with profound implications for our understanding of several normal functions, such as cellular signaling, as well as disease states, such as cardiovascular diseases or cancer. This understanding was accompanied by the development of innovative therapeutic strategies based on gasotransmitters, including carbon monoxide (CO), hydrogen sulfide (H2S), and nitric oxide (NO). Thus, over recent years, these molecules have gained significant attention for their potential use against a variety of disorders, making them also particularly relevant to the study of aging-related phenomena.
Aging is a multifaceted biological process characterized by the progressive decline of cellular functions and an increased susceptibility to age-related disorders. Researchers have increasingly recognized the potential of gasotransmitters to modulate various aspects of aging, such as cellular senescence, inflammation, mitochondrial function, and cardiovascular health. The intersection of gasotransmitter biology with pharmacy, nanomedicine, and medicinal chemistry opens up exciting avenues for developing targeted interventions aimed at promoting healthy aging and extending lifespan.
This article collection in Frontiers in Aging seeks to illuminate the latest breakthroughs in this burgeoning field, offering a comprehensive exploration of gasotransmitter-mediated pathways and their potential applications in the quest for a healthier and longer life.
The problem at the heart of this research topic lies in addressing the multifaceted challenges of aging and age-related diseases. As our global population continues to age, finding effective strategies to promote healthy aging and combat age-associated conditions is of paramount importance. Gasotransmitters, such as carbon monoxide (CO), hydrogen sulfide (H 2 S), and nitric oxide (NO), hold tremendous promise as signaling molecules that can influence key processes involved in aging.
Recent advances in gasotransmitter research have unveiled their roles in modulating oxidative stress, mitochondrial function, and inflammation, all of which are intricately linked to the aging process. However, the field is still in its infancy, and unlocking the full therapeutic potential of gasotransmitters requires a deeper understanding of their mechanisms of action and safe, targeted delivery methods. This Research Topic aims to bridge the gap between gasotransmitter biology, and their translational potential. By exploring innovative pharmacological interventions, CO-releasing molecules (CO-RMs), H 2 S-releasing molecules, and NO-based therapies, we can develop precise strategies for healthy aging and disease prevention. As recent breakthroughs continue to shed light on the nuances of gasotransmitter signaling, this collection of articles will pave the way for transformative approaches to enhance longevity and improve the quality of life for aging populations.
Authors are invited to contribute original research and review articles on gasotransmitter biology, focusing mainly on CO, also on H 2 S and NO, within the context of aging. Submissions should emphasize pharmacological interventions, safety, and translational potential, offering insights into how gasotransmitters can be harnessed for healthy aging and age-related disease management. The specific topics that are of interest include, but are not limited to:
1. Gasotransmitters as Signaling Molecules: Explore the diverse roles of endogenous gasotransmitters in cellular signaling pathways and their impact on the aging processes, including cellular senescence and inflammation.
2. Pharmacological Modulation of Gasotransmitters: Investigate the development of CO-releasing molecules (CO-RMs), nitric oxide-releasing molecules, hydrogen-sulfide-releasing molecules, and other pharmacological agents that target CO, NO or H 2 S pathways for potential applications in age-related diseases.
3. Gasotransmitters and Neurodegeneration: Examine the relationship between CO/NO/H 2 S signaling and neurodegenerative diseases, with a focus on potential neuroprotective agents based on gasotransmitters.
4. Gasotransmitters and Cardiovascular Health: Discuss the roles of CO/NO/H 2 S in vascular function and their implications for cardiovascular aging, as well as therapeutic approaches that target these pathways for heart health.
5. Mitochondrial Function and Gasotransmitters: Explore the impact of CO/NO/H 2 S on mitochondrial function, energy metabolism, and their potential as targets for age-related mitochondrial dysfunction.
6. Gasotransmitters in Anti-Aging Therapies: Investigate the potential of CO/NO/H 2 S-based interventions for promoting healthy aging and extending lifespan, including the use of CO/NO/H 2 S-releasing nanoparticles.
7. Safety and Clinical Translation: Address safety considerations, toxicity profiles, and the translational potential of CO/NO/H 2 S-based therapies for aging-related conditions.
Aging is a multifaceted biological process characterized by the progressive decline of cellular functions and an increased susceptibility to age-related disorders. Researchers have increasingly recognized the potential of gasotransmitters to modulate various aspects of aging, such as cellular senescence, inflammation, mitochondrial function, and cardiovascular health. The intersection of gasotransmitter biology with pharmacy, nanomedicine, and medicinal chemistry opens up exciting avenues for developing targeted interventions aimed at promoting healthy aging and extending lifespan.
This article collection in Frontiers in Aging seeks to illuminate the latest breakthroughs in this burgeoning field, offering a comprehensive exploration of gasotransmitter-mediated pathways and their potential applications in the quest for a healthier and longer life.
The problem at the heart of this research topic lies in addressing the multifaceted challenges of aging and age-related diseases. As our global population continues to age, finding effective strategies to promote healthy aging and combat age-associated conditions is of paramount importance. Gasotransmitters, such as carbon monoxide (CO), hydrogen sulfide (H 2 S), and nitric oxide (NO), hold tremendous promise as signaling molecules that can influence key processes involved in aging.
Recent advances in gasotransmitter research have unveiled their roles in modulating oxidative stress, mitochondrial function, and inflammation, all of which are intricately linked to the aging process. However, the field is still in its infancy, and unlocking the full therapeutic potential of gasotransmitters requires a deeper understanding of their mechanisms of action and safe, targeted delivery methods. This Research Topic aims to bridge the gap between gasotransmitter biology, and their translational potential. By exploring innovative pharmacological interventions, CO-releasing molecules (CO-RMs), H 2 S-releasing molecules, and NO-based therapies, we can develop precise strategies for healthy aging and disease prevention. As recent breakthroughs continue to shed light on the nuances of gasotransmitter signaling, this collection of articles will pave the way for transformative approaches to enhance longevity and improve the quality of life for aging populations.
Authors are invited to contribute original research and review articles on gasotransmitter biology, focusing mainly on CO, also on H 2 S and NO, within the context of aging. Submissions should emphasize pharmacological interventions, safety, and translational potential, offering insights into how gasotransmitters can be harnessed for healthy aging and age-related disease management. The specific topics that are of interest include, but are not limited to:
1. Gasotransmitters as Signaling Molecules: Explore the diverse roles of endogenous gasotransmitters in cellular signaling pathways and their impact on the aging processes, including cellular senescence and inflammation.
2. Pharmacological Modulation of Gasotransmitters: Investigate the development of CO-releasing molecules (CO-RMs), nitric oxide-releasing molecules, hydrogen-sulfide-releasing molecules, and other pharmacological agents that target CO, NO or H 2 S pathways for potential applications in age-related diseases.
3. Gasotransmitters and Neurodegeneration: Examine the relationship between CO/NO/H 2 S signaling and neurodegenerative diseases, with a focus on potential neuroprotective agents based on gasotransmitters.
4. Gasotransmitters and Cardiovascular Health: Discuss the roles of CO/NO/H 2 S in vascular function and their implications for cardiovascular aging, as well as therapeutic approaches that target these pathways for heart health.
5. Mitochondrial Function and Gasotransmitters: Explore the impact of CO/NO/H 2 S on mitochondrial function, energy metabolism, and their potential as targets for age-related mitochondrial dysfunction.
6. Gasotransmitters in Anti-Aging Therapies: Investigate the potential of CO/NO/H 2 S-based interventions for promoting healthy aging and extending lifespan, including the use of CO/NO/H 2 S-releasing nanoparticles.
7. Safety and Clinical Translation: Address safety considerations, toxicity profiles, and the translational potential of CO/NO/H 2 S-based therapies for aging-related conditions.
Keywords: Aging, Gasotransmitters, Carbon monoxide, Nitric oxide, Hydrogen Sulfide, Neurodegenerative diseases, Cardiovascular diseases
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
